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Activation of dendritic cells translates innate into adaptive immunity.
Vaccine Weekly
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April 21, 2004 |
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2004 APR 21 - (NewsRx.com & NewsRx.net) -- Activation of dendritic cells translates innate into adaptive immunity.
"Innate recognition of infection in vertebrates can lead to the induction of adaptive immune responses through activation of dendritic cells (DCs). DCs are activated directly by conserved pathogen molecules and indirectly by inflammatory mediators produced by other cell types that recognize such molecules. In addition, it is likely that DCs are activated by poorly characterized cellular stress molecules and by disturbances in the internal milieu," a researcher in England reports.
"The multiplicity of innate pathways for DC activation may have evolved to ensure that any signs of infection are detected early, before overwhelming pathogen replication," said Caetano Reis e Sousa at the London Research Institute. "Understanding which of these signs are both necessary and sufficient to convert DCs into the immunostimulatory antigen-presenting cells ...
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Source: HighBeam Research, Activation of dendritic cells translates innate into adaptive...