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Bacteria-mediated DNA transfer in gene therapy and vaccination reviewed.
2004 APR 21 - (NewsRx.com & NewsRx.net) -- Scientists review bacteria-mediated DNA transfer in gene therapy and vaccination in a recent issue of Expert Opinion on Biological Therapy.
According to researchers in Germany, "The use of live attenuated bacterial vaccine strains allows the targeted delivery of macromolecules to mammalian cells and tissues via the mucosal route. Depending on their specific virulence mechanisms and inherent metabolic preferences, bacteria invade certain cell types and body niches where they consequently deliver their cargo. Recently, the ability of attenuated strains of Salmonella, Shigella, and Yersinia species, as well as Listeria monocytogenes and invasive Escherichia coli, to deliver eukaryotic expression plasmids into mammalian cells in vitro and in vivo has been discovered."
"The great potential of bacteria-mediated transfer of plasmid DNA encoding vaccine antigens and/or therapeutic molecules was demonstrated in experimental animal models of infectious diseases, tumors, and gene deficiencies," stated Holger Loessner and Siegfried Weiss at the German Research Center for Biotechnology in Braunschweig. ...
- M. tuberculosis virulence locus regulates DNA transfer in M. smegmatis.
- Newspaper article from: Vaccine Weekly November 10, 2004 700+ words
...Mycobacterium tuberculosis regulates DNA transfer in Mycobacterium smegmatis. "Conjugal DNA transfer occurs by an atypical mechanism in Mycobacterium...acting factors required for mediating DNA transfer, a library of transposon insertion mutants...
- Factor VIII DNA transfer stimulates anti-transgene antibodies in mice.
- Newspaper article from: Blood Weekly October 14, 2004 700+ words
...14 - (NewsRx.com & NewsRx.net) -- Factor VIII DNA transfer stimulates anti-transgene antibodies in mice. According...the results of their research in Molecular Therapy (Naked DNA transfer of factor VIII induced transgene-specific, species-independent...
- GLI3 gene truncation causes mitochondrial-nuclear DNA transfer and disease.
- Newspaper article from: Genomics & Genetics Weekly May 23, 2003 700+ words
...truncation of the GLI3 gene causes de novo mitochondrial-nuclear DNA transfer that appears to cause Pallister-Hall syndrome, usually...genetic disease caused by de novo mitochondrial-nuclear DNA transfer. Hum Genet, 2003;112(3):303-309). For additional...
- In vivo plasmid DNA transfer identifies neurone-specific gene promoters.
- Newspaper article from: Health & Medicine Week November 8, 2004 700+ words
2004 NOV 8 - (NewsRx.com & NewsRx.net) -- In vivo plasmid DNA transfer identifies neuron-specific gene promoters. "We utilized the retrograde transport machinery of neurons to deliver naked plasmid...
- Gold nanoparticles enhance polyethylenimine-mediated plasmid DNA transfer.
- Newspaper article from: Biotech Week October 8, 2003 700+ words
...2003 OCT 8 - (NewsRx.com & NewsRx.net) -- Gold nanoparticles enhance polyethylenimine-mediated plasmid DNA transfer. According to published research from the United States, "branched polyethylenimine (PEI) chains with an average...
- Electric field-induced molecular vibration forges DNA transfer.
- Newspaper article from: Gene Therapy Weekly July 1, 2004 700+ words
2004 JUL 1 - (NewsRx.com & NewsRx.net) -- Electric field-induced molecular vibration forges DNA transfer. "Gene delivery is an essential research tool for elucidating gene structure, regulation, and function in biomedical research...
- Experts back doc's DNA transfer theory.(News)
- Newspaper article from: The Boston Herald Farmer, Tom June 22, 2001 700+ words
Two genetic experts testifying for accused wife-murderer Dr. Dirk Greineder said it's possible the Wellesley allergist's DNA could have been on his wife when she was murdered and transferred to the gloves and knife used by her mystery killer. Greineder, 60, says someone else beat and stabbed his
- Expert Opinion on Drug Safety Launches an Open-Access Correspondence Section.
- Press release article from: PR Newswire January 6, 2006 700+ words
...regulatory affairs. Over the last year, Expert Opinion on Drug Safety has seen an increase...eds. Published six times a year, Expert Opinion on Drug Safety seeks to unravel the...guides. Each article contains an 'Expert Opinion' section, in which authors are encouraged...
