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Natural killer T-like cells induced by thymoma expressing alpha-fetoprotein.
2004 APR 21 - (NewsRx.com & NewsRx.net) -- CD4+ murine natural killer T-like cells were induced by immunization with syngeneic thymoma expressing embryonic alpha-fetoprotein.
According to a study from Japan, "In embryo, before the establishment of acquired immunity, a variety of embryonic antigens like a-fetoprotein (AFP) are produced and secreted in the sera, which rapidly disappear after the birth. Such embryonic antigens sometimes reappear from various tumor cells and decrease in the case of remission, indicating embryonic antigens may alert immune system to control tumors. In the present study, to examine the evoked immune responses against the tumors expressing embryonic antigen, we administered AFP-gene-transfected EL4 cells into syngeneic C57BL/6 mice and established a killer line against the tumor cells."
"To our surprise, the killer line was CD4+ NK1.1+, natural killer T (NKT)-like cells and eliminated not only AFP-expressing EL4 but YAC-1 cells," said Youngsoon Kim and colleagues at Nippon Medical School. "Moreover, the established line uniformly expressed ...
- Natural killer T-like cells induced by thymoma expressing alpha-fetoprotein.
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