AccessMyLibrary provides FREE access to over 30 million articles from top publications available through your library.
Create a link to this page
Copy and paste this link tag into your Web page or blog:
Immunogenicity of recombinant BCG vaccine strains investigated.
2004 APR 21 - (NewsRx.com & NewsRx.net) -- Researchers have investigated the immunogenicity of recombinant BCG vaccine strains overexpressing components of the antigen 85 complex of Mycobacterium tuberculosis.
According to a study from India, "The components of antigen 85 complex of Mycobacterium tuberculosis (Ag 85A, Ag 85B and Ag 85C), due to their immunodominant and secretory nature, represent promising protective antigen candidates and have been used in numerous vaccine preparations. We have used recombinant Bacille Calmette-Guerin (BCG) strains overexpressing Ag 85A and Ag 85C to immunize BALB/c mice to investigate the immunogenicity of these strains."
"Mice immunized with recombinant BCG strains exhibited an increased humoral immune response when compared to mice immunized with wild-type BCG," reported N. Dhar and colleagues at the University of Delhi. "The recombinant BCG strain overexpressing Ag 85A also induced an increased Th1-like response, characterized by elevated levels of IFN-gamma in antigen stimulated splenocyte cultures and a strong IgG2a antibody response, when compared to wild-type BCG. ...
- Immunogenicity of recombinant BCG vaccine strains investigated.
- Newspaper article from: Drug Week April 23, 2004 700+ words
...the immunogenicity of recombinant BCG vaccine strains overexpressing components...BCG. Immunization with recombinant BCG strain overexpressing...Immunology (Immunogenicity of recombinant BCG vaccine strains overexpressing components...
- MEDIMMUNE REPORTS RECOMBINANT BCG VACCINE PREVENTS LYME DISEASE IN ANIMAL...
- Press release article from: PR Newswire July 1, 1993 700+ words
...demonstrates the use of MedImmune's recombinant BCG vaccine technology to completely prevent...clearly demonstrates the power of recombinant BCG as a vehicle for vaccination," said...this study shows the potential of our recombinant BCG technology to be applied to a number...
- Recombinant BCG DNA vaccines and gene immunotherapy treat bladder cancer.
- Newspaper article from: Cancer Weekly April 13, 2004 700+ words
...NewsRx.com & NewsRx.net) -- Recombinant BCG DNA vaccines and gene immunotherapy...2) cells. We used four combined recombinant BCG DNA vaccines (poly-rBCG) for electroporative...treatment of bladder cancer using recombinant BCG DNA vaccines," scientists concluded...
- Neutralizing Antibodies Against DPT Induced by Recombinant BCG.(new diphtheria,...
- Newspaper article from: Immunotherapy Weekly February 14, 2001 700+ words
...Instituto Butantan, Sao Paulo. "With the aim of developing a recombinant BCG (rBCG) vaccine against DPT, we analyzed the potential...diphtheria, pertussis, and tetanus (DPT) vaccine protocol * Recombinant BCG was modified to express CRM197, a mutant diptheria toxin...
- Neutralizing Antibodies Against DPT Induced by Recombinant BCG.
- Newspaper article from: TB & Outbreaks Week February 13, 2001 700+ words
...Instituto Butantan, Sao Paulo. "With the aim of developing a recombinant BCG (rBCG) vaccine against DPT, we analyzed the potential...diphtheria, pertussis, and tetanus (DPT) vaccine protocol * Recombinant BCG was modified to express CRM197, a mutant diptheria toxin...
- Neutralizing Antibodies Against DPT Induced by Recombinant BCG.(Brief Article)
- Newspaper article from: Vaccine Weekly February 14, 2001 700+ words
...Instituto Butantan, Sao Paulo. "With the aim of developing a recombinant BCG (rBCG) vaccine against DPT, we analyzed the potential...diphtheria, pertussis, and tetanus (DPT) vaccine protocol * Recombinant BCG was modified to express CRM197, a mutant diptheria toxin...
- Recombinant BCG Vaccines Confer More Potent Protective Immunity.
- Newspaper article from: TB & Outbreaks Week December 26, 2000 700+ words
...highly susceptible animal model," PNAS, December 5, 2000,97(25):13853-13858). "Animals immunized with the recombinant BCG vaccines and challenged by aerosol with a highly virulent strain of M. tb had 0.5 logs fewer M. tb bacilli in their...
- Recombinant BCG Vaccines Confer More Potent Protective Immunity.(Brief Article)
- Newspaper article from: Vaccine Weekly December 27, 2000 700+ words
...highly susceptible animal model," PNAS, December 5, 2000,97(25):13853-13858). "Animals immunized with the recombinant BCG vaccines and challenged by aerosol with a highly virulent strain of M. tb had 0.5 logs fewer M. tb bacilli in their...