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Lactic acid bacteria and allergen induce immune response in allergy model.

Vaccine Weekly

| April 21, 2004 | COPYRIGHT 2004 NewsRX. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan.  All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)Copyright

2004 APR 21 - (NewsRx.com & NewsRx.net) -- Mucosal co-application of lactic acid bacteria and allergen induces counter-regulatory immune responses in a murine model of birch pollen allergy.

According to a study from Austria and France, "Recent epidemiological studies and clinical trials suggest a possible role of certain lactic acid bacteria (LAB) strains in the prevention of allergic diseases. In this study, we aimed at evaluating the immunomodulatory potential of two LAB strains, Lactococcus lactis and Lactobacillus plantarum, for prophylaxis and therapy of allergic immune responses."

"Both LAB strains-induced high levels of IL-12 and IFN-gamma in naive murine spleen cell cultures," reported Andreas Repa and collaborators at the Universities of Vienna and Salzburg in Austria and the Institut Pasteur de Lille in France. "Intranasal co-application with recombinant Bet v 1, the major birch pollen allergen, prior or after allergic sensitization, led to increased levels of allergen-specific IgG2a antibodies and in vitro IFN-gamma production, indicating a shift towards Th1 responses. Successful immunomodulation by the mucosal pre-treatment was further demonstrated by suppression of ...

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Source: HighBeam Research, Lactic acid bacteria and allergen induce immune response in allergy...

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