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Live sporozoite vaccine under chloroquine therapy protects against malaria.
2004 APR 21 - (NewsRx.com & NewsRx.net) -- Protective T cell immunity against malaria liver stage occurred after vaccination with live sporozoites under chloroquine treatment.
According to recent research from France and Brazil, "In this study we present the first systematic analysis of the immunity induced by normal Plasmodium yoelii sporozoites in mice. Immunization With sporozoites, which was conducted under chloroquine treatment to minimize the influence of blood stage parasites, induced a strong protection against a subsequent sporozoite and, to a lesser extent, against infected RBC challenges. The protection induced by this immunization protocol proved to be very effective."
"Induction of this protective immunity depended on the presence of liver stage parasites, as primaquine treatment concurrent with sporozoite immunization abrogated protection," said Elodie Belnoue at INSERM U567 and collaborators in France and Brazil. "Protection was not found to be mediated by the antibodies elicited against pre-erythrocytic and blood stage parasites, as demonstrated by inhibition assays of sporozoite penetration or development in vitro and in vivo assays of sporozoite infectivity or blood stage parasite development. CD4+ ...
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