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Fatal human influenza A subtype H5N1 disease re-emerges.

Vaccine Weekly

| April 21, 2004 | COPYRIGHT 2004 NewsRX. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan.  All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)Copyright

2004 APR 21 - (NewsRx.com & NewsRx.net) -- Fatal human influenza A subtype H5N1 disease has re-emerged.

According to recent research published in the journal Lancet, "Human disease associated with influenza A subtype H5N1 re-emerged in January, 2003, for the first time since an outbreak in Hong Kong in 1997. Patients with H5N1 disease had unusually high serum concentrations of chemokines (e.g., interferon induced protein-10 [IP-10] and monokine induced by interferon gamma [MIG])."

"Taken together with a previous report that H5N1 influenza viruses induce large amounts of proinflammatory cytokines from macrophage cultures in vitro, our findings suggest that cytokine dysfunction contributes to the pathogenesis of H5N1 disease," said Joseph S. Malik Peiris and collaborators at the University of Hong Kong, Princess Margaret Hospital, and the Hong Kong Department of Health. "Development ...

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