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Assays with extended incubation phases needed to monitor HIV vaccine trials.
2004 APR 21 - (NewsRx.com & NewsRx.net) -- The first generation of candidate HIV-1 vaccines can induce antibodies able to neutralize primary isolates in assays with extended incubation phases.
According to published research from Belgium, "Quantification of human immunodeficiency virus type 1 (HIV-1) neutralizing antibodies is considered to be an important parameter in evaluating candidate vaccines. Most previous studies have failed to detect vaccine-induced antibodies against primary isolates, which are more resistant to antibody mediated neutralization compared with laboratory isolates, in neutralization assays."
"In this study, sera from a prime boost vaccination strategy of a phase I clinical trial were tested against six clade B primary HIV-1 isolates and single isolates of clades C and E," said wrote Helen Donners and colleagues at the Institute of Tropical Medicine in Antwerp. "These sera produced statistically significant neutralization against primary isolates MN, SF13, SF162 and Han 2 but not the most resistant subtype B isolates (92US077 and 93US143) nor the subtype C and F isolates. These data suggest that the sera ...
- Assays with extended incubation phases needed to monitor HIV vaccine trials.
- Newspaper article from: Health & Medicine Week April 19, 2004 700+ words
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