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Efficacy of tuberculosis DNA vaccine varies with method of DNA introduction.
2004 APR 21 - (NewsRx.com & NewsRx.net) -- Efficacy of DNA-hsp65 vaccination for tuberculosis varies with method of DNA introduction in vivo.
"A DNA vaccine codifying the mycobacterial hsp65 can prevent infection with Mycobacterium tuberculosis in a prophylactic setting and also therapeutically reduce the number of bacteria in infected mice. The protective mechanism is thought to be related to Th1-mediated events that result in bacterial killing," investigators in Brazil report.
"To determine the best method of hsp65 introduction for vaccination efficacy against tuberculosis (TB), we evaluated the immunogenicity and protection of DNA-hsp65 administered by gene gun bombardment or intramuscular (i.m.) injection of naked DNA," said Karla M. Lima and colleagues at the University of Sao Paulo. "Immunization by gene gun induced immune response with plasmid doses 100-fold lower than those required for intramuscular immunization. However, in contrast to intramuscular immunization, which was protective in these studies, gene gun ...
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Source: HighBeam Research, Efficacy of tuberculosis DNA vaccine varies with method of DNA...