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Chemokine gene modification of dendritic cells improves antitumor activity.
2004 APR 14 - (NewsRx.com & NewsRx.net) -- Chemokine gene modification of dendritic cells improves antitumor activity.
"Previous animal studies conducted in our laboratory have shown that tumor antigen-pulsed dendritic cells (TP-DC) can mediate antitumor effects in vivo. However, durable and complete regression of established tumors has been difficult to achieve through the administration of TP-DC alone. To better augment immune priming to tumors in vivo, we have hypothesized that it is necessary to achieve an increased number of host-derived, naive T cells at the site of TP-DC vaccine injections," scientists writing in the journal Cancer Gene Therapy report.
"To accomplish this goal, we have embarked on a series of studies that utilize defined chemokines. One of these molecules, secondary lymphoid tissue chemokine (SLC), has been shown to be uniquely chemoattractant for naive T cells and dendritic cells. We propose that gene modification of DC-based tumor vaccines to produce human SLC will enhance T-cell recruitment and immune priming to tumor-associated antigens, and thereby translate into improved antitumor vaccine efficacy in vivo," said A. Terando and colleagues, H. Lee Moffit Cancer Center & Research Institute.
"Utilizing an E1-, E3-deleted adenoviral vector containing the gene for human SLC, we have been able to transduce human DC to produce biologically active human SLC that chemoattracts ...
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Source: HighBeam Research, Chemokine gene modification of dendritic cells improves antitumor...