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Vaccinia virus infections treated with ether lipid esters of cidofovir.
2004 APR 7 - (NewsRx.com & NewsRx.net) -- Cowpox and vaccinia virus infections in mice were treated with ether lipid esters of cidofovir.
According to recent research from the United States, "Four newly synthesized ether lipid esters of cidofovir (CDV), hexadecyloxypropyl-CDV (HDP-CDV), octadecyloxyethyl-CDV (ODE-CDV), oleyloxypropyl-CDV (OLP-CDV), and oleyloxyethyl-CDV (OLE-CDV), were found to have enhanced activities against vaccinia virus (W) and cowpox virus (CV) in vitro compared to those of CDV. The compounds were administered orally and were evaluated for their efficacies against lethal CV or W infections in mice."
"HDP-CDV, ODE-CDV, and OLE-CDV were effective at preventing mortality from CV infection when treatments were initiated 24 hours after viral inoculation, but only HDP-CDV and ODE-CDV maintained efficacy when treatments were initiated as late as 72 hours post-infection," reported Debra C. Quenelle and collaborators at the University of Alabama and the University of California-San Diego. "Oral pretreatment with HDP-CDV and ODE-CDV were also effective when they were given 5, 3, or 1 day prior to inoculation with CV, even when each compound was administered as a single dose. Both HDP-CDV and ODE-CDV were also effective against W infections when they were administered orally 24 or 48 hours after infection."
Quenelle and her colleagues found, "In animals treated with HDP-CDV or ODE-CDV, ...
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Source: HighBeam Research, Vaccinia virus infections treated with ether lipid esters of...