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Vaccine improves antibody levels in hematopoietic cell transplant patients.
2004 APR 7 - (NewsRx.com & NewsRx.net) -- Recipient vaccination both before and early after hematopoietic cell transplantation increases protective antibody levels.
"Allogeneic hematopoietic cell transplantation is followed by humoral immunodeficiency. We evaluated whether antibody levels can be improved by recipient vaccination on days -1 and 50 and whether the levels can be further improved by donor vaccination on day -20. A total of 85 patients were randomized or assigned to one of the following strategies of immunization with Streptococcus pneumoniae polysaccharides, Haemophilus influenzae polysaccharide-protein conjugate, tetanus toxoid (protein recall antigen), and hepatitis B surface antigen (protein neo-antigen): donor on day -20, recipient on days -1, +50 and +365 (D-20R-1,50,365); donor nil, recipient on days -1, +50 and +365 (DNR-1,50,365); or donor nil, recipient on day +365 (DNR365)," scientists in the United States report.
"For H. influenzae and tetanus, IgG levels after grafting were the highest in the D-20R-1,50,365 patients, intermediate in the DNR-1,50,365 patients, and the lowest in the DNR365 patients," stated J. Storek and colleagues at the University of Washington and the Fred Hutchinson Cancer Research Center in Seattle. "For S. pneumoniae and hepatitis B, antibody levels appeared to be similar in all three patient groups."
"The ...
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