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GM-CSF immobilized onto particulate vaccine carrier systems.
2004 APR 7 - (NewsRx.com & NewsRx.net) -- Researchers have developed a method to immobilize granulocyte-macrophage colony-stimulating factor (GM-CSF) onto particulate vaccine carrier systems.
According to recent research published in the International Journal of Pharmaceutics, "Physical connection of vaccine carriers with immunostimulating cytokines may provide an interesting possibility to enhance the immune response of protective or therapeutic vaccines. As a first evaluation, various aluminum hydroxide adjuvants and poly(D,L-lactide-co-glycolide) (PLGA) microparticulates with modified positively and negatively charged surfaces were prepared to adsorb granulocyte-macrophage colony-stimulating factor (GM-CSF) under different pH conditions."
"Negatively charged surfaces were chosen to resemble physiological binding of GM-CSF to extracellular glycosaminoglycans, while modified positively charged surfaces may enhance GM-CSF adsorption due to electrostatic interaction," said Barnali Mandal and colleagues at the Swiss Federal Institute of Technology. "Release of GM-CSF was checked in vitro in a simulated interstitial environment. Anionic and cationic surfaces efficiently attracted GM-CSF to the carrier surface independently of the pH, while the composition of the carrier largely influenced the release of ...
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