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Bacterial clearance from respiratory tract requires complement component C3.
2004 APR 7 - (NewsRx.com & NewsRx.net) -- Antibody-mediated bacterial clearance from the lower respiratory tract of mice requires complement component C3.
According to a study from the United States, "To assess the contribution of complement to respiratory immunity in the context of a natural bacterial infection, we used mice genetically deficient in complement components and the murine pathogen Bordetella bronchiseptica. Complement component C3 was not required for the control of bacterial infection or for the generation of infection-induced protective immunity. However, C3-deficient (C3[superscript]-/-) mice were severely defective, compared to wild type, in vaccine-induced protective immunity."
"Adoptively transferred immune serum from convalescent wild-type or C3[superscript]-/- animals rapidly cleared B. bronchiseptica from the lungs of wild-type mice but did not affect its growth in C3[superscript]-/- mice, indicating that the defect is not in the generation of protective immunity, but in its function," reported Elizabeth J. Pishko and colleagues at Pennsylvania State University. "Immune serum was effective in C5-deficient mice but had little effect in the lungs of mice lacking either Fcgamma receptors (FcgammaR) or CR3, suggesting ...
- Complement component 3 required for expansion of CD8 cells in viral infections.
- Newspaper article from: Immunotherapy Weekly March 5, 2003 700+ words
...to its established role in innate immune mechanisms, complement component C3 is also of critical importance in B cell activation...published their study in the Journal of Immunology (Complement component 3 is required for optimal expansion of CD8 T cells during...
- Complement Component C5 Required for Active Arthritis.
- Newspaper article from: Immunotherapy Weekly May 7, 2000 700+ words
...a scientific study in a recent issue of the Journal of Immunology demonstrating that animals deficient in the complement component C5 are not susceptible to the onset of active arthritis. Alexion is currently conducting a Phase II multi...
- Human complement component C8: expression of C8[gamma] subunit in E. coli....
- Magazine article from: Bulletin of the South Carolina Academy of Science Chiswell, Brian Sodetz, J.M. January 1, 2003 700+ words
C8[gamma] is a 22-kDa subunit of human C8, which is one of five proteins that form the cytolytic "membrane attack complex" of complement on target cells. Among the complement proteins, C8[gamma] is unique in that it is the only lipocalin. Lipocalins are a large family of proteins with the common
- Human Complement Component C8: Structure-Function Analysis of the C8[gamma]...
- Magazine article from: Bulletin of the South Carolina Academy of Science Parker, Chasta Ortlund, Eric Schreck, Steven F. Lebioda, Lukasz Sodetz, James M. January 1, 2001 700+ words
Human C8 is one of five complement components (C5b, C6, C7, C8, C9) that assemble on the surface of pathogenic organisms to form a cytolytic "membrane attack complex" (MAC). It is composed of an [alpha] (64kDa), [beta] (64kDa), and [gamma] (22kDa) subunit, which are arranged as a disulfide-linked
- Immunologic aspacts of lens induced ocular reactions: Complement component...
- Magazine article from: Indian Journal of Ophthalmology Saraf, R. Gupta, A. Sarin, G. December 1, 1983 700+ words
Byline: R. Saraf, A. Gupta, G. Sarin Ocular reactions induced by lens can be caused by either the toxic effects of the lenticular material or allergic phenomenon. The immune reaction which has been incriminated quite fre-quently in the causation of lens induced ocular reactions is antibody mediated
- Study data from University of Iowa update knowledge of sepsis.
- Newspaper article from: Blood Weekly August 28, 2008 700+ words
...like growth factor (IGF)-1 and bacterial clearance by Kupffer cells are significantly...decline in IGF-1 is related to bacterial clearance in sepsis. Sepsis was induced in...alpha and IL-6, improved hepatic bacterial clearance as demonstrated by real-time polymerase...
- New sepsis study findings have been published by scientists at Cincinnati...
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...inflammation at the expense of altered bacterial clearance and, thus, higher mortality in...tolerance significantly improved bacterial clearance in both blood and peritoneal fluid...inflammatory response, augments bacterial clearance, and improves survival in this...
- Studies from University of California update current data on influenza.
- Newspaper article from: Virus Weekly September 29, 2009 700+ words
...persistent inflammation with impaired bacterial clearance compared to controls. While wild...mice showed impaired early bacterial clearance and loss of TLR2 induction in early...TLR2 activation is critical for bacterial clearance and timely resolution of otitis...
