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P. falciparum parasitophorous vacuole membrane protein investigated.
2004 APR 7 - (NewsRx.com & NewsRx.net) -- Scientists have performed a functional analysis of Plasmodium falciparum parasitophorous vacuole membrane protein (Pfs16) during gametocytogenesis and gametogenesis by targeted gene disruption.
According to a study from the United States, "Gametocytogenesis is a tightly regulated process marked by differentiation through distinct morphological forms and coordinated expression of sexual stage gene products. The earliest known gene product expressed at the onset of Plasmodium falciparum gametocytogenesis is Pfs16 localized on the parasitophorous vacuole membrane (PVM). Targeted gene disruption was undertaken to disrupt expression of Pfs16 and examine its potential role during sexual development."
"Three independent clones were demonstrated to have the coding sequence of Ps16 gene disrupted by the targeting plasmid by homologous recombination," reported Darin Kongkasuriyachai and collaborators at Johns Hopkins University and Case Western Reserve University. "No full-length transcripts and PVM localized 16 kDa protein were detected. Instead, all three '16ko' clones expressed a protein of 14 kDa recognized by Pfs16 specific antibodies that was mislocalized to an unidentified double membrane compartment in the parasites. Disruption of Pfs16 gene resulted in a significant reduction in gametocyte production, although the small number of gametocytes produced appeared to be normal by molecular and phenotypic evidences."
"Preliminary ...
- P. falciparum parasitophorous vacuole membrane protein investigated.
- Newspaper article from: Genomics & Genetics Weekly April 9, 2004 700+ words
...Plasmodium falciparum parasitophorous vacuole membrane protein (Pfs16...localized on the parasitophorous vacuole membrane (PVM). Targeted...Plasmodium falciparum parasitophorous vacuole membrane protein (Pfs16...
- Researchers' work from Cleveland State University focuses on falciparum malaria.
- Newspaper article from: Malaria Weekly (Atlanta, GA) April 20, 2009 700+ words
...intracellular blood stage, and immunoelectron microscopy shows domains of PfMC-2TM localized in the parasitophorous vacuole and parasitophorous vacuole membrane," wrote I. Tsarukyanova and colleagues, Cleveland State University (see also Falciparum...
- Studies from University of Gottingen further understanding of eukaryotic...
- Newspaper article from: Life Science Weekly September 30, 2008 700+ words
...common entry strategies, the formation of the parasitophorous vacuole (PV) in Encephalitozoon species is likely...their study in Eukaryotic Cell (The nascent parasitophorous vacuole membrane of Encephalitozoon cuniculi is formed by...
- New structures research from University of Montpellier described.
- Newspaper article from: Science Letter March 17, 2009 700+ words
...Our ROP2 structure rules out a previous structural model of attachment of ROP2-like proteins to the parasitophorous vacuole membrane," wrote G. Labesse and colleagues, University of Montpellier (see also Structures). The researchers...
- New falciparum malaria research from University of Kiel outlined.
- Newspaper article from: Malaria Weekly (Atlanta, GA) July 28, 2008 700+ words
...negatively charged plasma membrane of the infected host cell and traverses this membrane as well as the parasitophorous vacuole membrane to reach its final target, the intracellular parasite," wrote C. Gelhaus and colleagues, University...
- New falciparum malaria study findings reported from Institute Pasteur.(Report)
- Newspaper article from: Malaria Weekly (Atlanta, GA) September 1, 2008 700+ words
...distinct gene products, RhopH1, RhopH2, and RhopH3, is known to be secreted and transferred to the parasitophorous vacuole membrane upon invasion of a red blood cell by the malaria parasite Plasmodium falciparum." "Here we show that...
- Studies from University of Michigan, Medical Department yield new data on...
- Newspaper article from: Life Science Weekly February 17, 2009 700+ words
...entrapment within host cells. We show that this defect is due to an inability to rapidly permeabilize the parasitophorous vacuole membrane and host plasma membrane during exit. TgPLP1 ablation had little effect on growth in culture but resulted...
- Membrane Transport in the Malaria-Infected Erythrocyte.
- Magazine article from: Physiological Reviews KIRK, KIARAN April 1, 2001 700+ words
...their functional characteristics have been described in some detail. The transport properties of the "parasitophorous vacuole" membrane (PVM) in which the intracellular parasite is enclosed, the parasite plasma membrane (PPM), and the...
- Research conducted at Osaka City University has provided new information about...
- Newspaper article from: Science Letter May 12, 2009 700+ words
...untreated cells and was enriched in the vacuole membrane in response to amphotericin B (AmB...induced ergosterol enrichment in the vacuole membrane, resulting in increased sensitivity...inhibitory to ergosterol enrichment in the vacuole membrane that was achieved by its external...
- Dream Home: Malaria Parasite Renovates to Suit Its Tastes.
- News wire article from: Ascribe Higher Education News Service December 9, 2004 700+ words
...the parasite membrane, the parasitophorous vacuole and the erythrocyte membrane...across the second membrane, the parasitophorous vacuole, and establishes infection in...said Cowman. "Once past the parasitophorous vacuole it can renovate the erythrocyte...
Source: HighBeam Research, P. falciparum parasitophorous vacuole membrane protein investigated.