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Expression by DNA-transfected DCs occurs through terminal differentiation.
2004 APR 7 - (NewsRx.com & NewsRx.net) -- Highly efficient expression of transgenic proteins by naked DNA-transfected dendritic cells (DCs) occurs through terminal differentiation.
"Dendritic cells play a key role in the induction and control of immunity. Genetic engineering of DCs is a promising approach for the development of a broad range of immunomodulatory strategies, for purposes ranging from genetic immunization to tolerance induction. The development of DC-based immunotherapies is limited by the inability to efficiently transfect DCs using naked DNA," researchers in the United States report.
"Here we demonstrate that after plasmid DNA delivery, the transgene expression level controlled by the human immediate-early cytomegalovirus promoter (hlE-CMVp) is higher in mature DCs than in immature DCs and is further increased after terminal differentiation of DCs by agonist anti-CD40 monoclonal antibody (mAb) or after DC interaction with CD4+ T cells," stated Adriana T. Larregina and colleagues at the University of Pittsburgh. "CD40 signaling of DCs resulted in nuclear translocation of the transcription factors nuclear factor-kappaB (NF-kappaB), activator of protein-1 (AP-1), and cyclic adenosine monophosphate (cAMP)-responsive element, necessary for the activation of hIE-CMVp."
"Transgene expression by DCs diminished after the ...
- In terminal differentiation, there is increased Nix and Bcl-xL expression.
- Newspaper article from: Biotech Week September 17, 2003 700+ words
2003 SEP 17 - (NewsRx.com & NewsRx.net) -- During erythropoiesis, Nix is expressed along with Bcl-xL with a perinuclear mitochondrial expression pattern. According to published research from the United States, "Transcriptional profiles of cultured primary human erythroid cells were examined to
- Immunology "Type I IFNs Enhance the Terminal Differentiation of Dendritic...
- Newspaper article from: Immunotherapy Weekly September 28, 1998 700+ words
Journal of Immunology, August 15, 1998;161(4):1947-1953. Luft, T.; Pang, K.C.; Thomas, E.; Hertzog, P.; Hart, D.N.J.; Trapani, J.; Cebon, J. According to the authors' abstract of an article published in Journal of Immunology, "This study identifies type I IFNs as activating cytokines in a
- The role of apoptosis in human epidermal keratinocytes.
- Magazine article from: Journal of Drugs in Dermatology Weisfelner, Michelle Emily Gottlieb, Alice B August 1, 2003 700+ words
...similarities and distinctions between terminal differentiation and apoptosis in keratinocytes...types such as lymphocytes (1). Terminal Differentiation versus Apoptosis Several authors...that in epidermal keratinocytes, terminal differentiation is a specialized form of apoptosis...
- Study findings on enzyme research are outlined in reports from S.M. Janes and...
- Newspaper article from: Gene Therapy Weekly July 9, 2009 700+ words
...human epidermal keratinocytes to terminal differentiation. Phosphorylated Akt and caspase...inhibited suspension-induced terminal differentiation. Caspase inhibition also blocked...the onset of expression of the terminal differentiation marker involucrin by several hours...
- New leukemia study findings have been reported from University of Washington.
- Newspaper article from: Proteomics Weekly September 8, 2008 700+ words
...myeloid progenitor cells and blocks terminal differentiation," investigators in the United...regulation of Cdk1 and induction of terminal differentiation. To investigate whether Cdk1...expressing L-G cells to undergo terminal differentiation. In addition, siRNA knockdown...
- Researchers at Cleveland Clinic publish new data on hormones.(Report)
- Newspaper article from: Biotech Week March 25, 2009 700+ words
...that thyroid hormone regulates terminal differentiation of growth plate chondrocytes through...beta-catenin signaling and terminal differentiation of growth plate chondrocytes...catenin signaling and promotes the terminal differentiation of growth plate cells. Overexpression...
- RNA degradation by hPNPase(')(Old-35) is common maintenance factor.
- Newspaper article from: Proteomics Weekly March 3, 2003 700+ words
...study from the United States, "Terminal differentiation and cellular senescence display...physiological changes associated with terminal differentiation and senescence, an overlapping...growth control associated with terminal differentiation and cellular senescence." Leszczyniecka...
- Reports summarize life sciences research from H. Yahi and co-authors.
- Newspaper article from: Biotech Week September 24, 2008 700+ words
...integrated system, skeletal muscle terminal differentiation. In this system, terminal differentiation is initiated by the transcription...target gene expression and muscle terminal differentiation. Together, our data show a...