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Trial results advance development of vaccine for travelers' diarrhea.
2004 APR 7 - (NewsRx.com & NewsRx.net) -- A clinical trial undertaken by the U.K. biotechnology company Microscience at the St. George's Vaccine Institute at St. George's Hospital Medical School in London, England has demonstrated the safety and immunogenicity of a new oral vaccine that is intended to protect against the infectious enterotoxigenic Escherichia coli disease (ETEC), the commonest cause of travelers' diarrhea.
The trial at St. George's was a dose-escalating, open-label study involving 36 volunteers. The primary aim of the study was to assess the safety and determine the serum antibody and mucosal responses raised by this novel vaccine. The results showed that the vaccine had an excellent safety profile and was highly immunogenic. After a single dose, 50% of the volunteers mounted high levels of immune responses against a known protective antigen of ETEC. After two doses the response rate rose to 70%.
"The results ...
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Source: HighBeam Research, Trial results advance development of vaccine for travelers' diarrhea.