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Immunization attenuates psychoactive effects of nicotine.
2004 APR 7 - (NewsRx.com & NewsRx.net) -- Immunization attenuates the psychoactive effects of nicotine.
"Despite the enormous health risks, people continue to smoke and use tobacco primarily as a result of nicotine addiction. As part of our immunopharmacotherapy research, the effects of active and passive immunizations on acute nicotine-induced locomotor activity in rats were investigated. To this end, rats were immunized with either a NIC-KLH immunoconjugate vaccine designed to elicit an antinicotine immune response, or were administered an antinicotine monoclonal antibody, NIC9D9, prior to a series of nicotine challenges and testing sessions," scientists writing in the journal Bioorganic and Medicinal Chemistry report.
"Vaccinated rats showed a 45% decrease in locomotor activity compared to a 16% decrease in controls," said M. Rocio A. Carrera and colleagues at Scripps Research Institute in the United States. "Passive immunization with NIC9D9 resulted in a 66.9% decrease in locomotor activity versus a 3.4% decrease in controls. Consistent with the behavioral data, much less nicotine was found in ...
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Source: HighBeam Research, Immunization attenuates psychoactive effects of nicotine.