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Microglial activation facilitates A-beta plaque removal.
2004 APR 7 - (NewsRx.com & NewsRx.net) -- Microglial activation facilitates A-beta plaque removal following intracranial anti-A beta antibody administration.
According to a study from the United States, "The mechanisms by which anti-A-beta antibodies clear amyloid plaques in A-beta depositing transgenic mice are unclear. In the current study, we demonstrate that inhibition of anti-A-beta antibody-induced microglial activation with anti-inflammatory drugs, such as dexamethasone, inhibits removal of fibrillar amyloid deposits. We also show that anti-A-beta F(ab')[subscript]2 fragments fail to activate microglia and are less efficient in removing fibrillar amyloid than the corresponding complete IgG."
"Diffuse A deposits are cleared by antibodies under all circumstances," reported Donna M. Wilcock and colleagues at the University of South Florida and Rinat Neuroscience Corporation. "These data suggest that microglial activation is necessary for efficient removal of compact amyloid deposits with immunotherapy. Inhibition of this ...
- Microglial activation facilitates A-beta plaque removal.
- Newspaper article from: Drug Week April 9, 2004 700+ words
...induced microglial activation with anti...University of South Florida and Rinat...suggest that microglial activation is necessary...Disease (Microglial activation facilitates...University of South Florida, 12901 Bruce...
- Brain cholinergic pathway regulates microglial activation through nAChR.
- Newspaper article from: Angiogenesis Weekly June 18, 2004 700+ words
...Brain cholinergic pathway regulates microglial activation through nAChR. According to recent...in the brain that could regulate microglial activation." Shytle continued, "Here we...cholinergic pathway that regulates microglial activation through alpha7 nicotinic receptors...
- MCP-1 levels are elevated in CSF of ALS patients, due to microglial activation.
- Newspaper article from: Hematology Week January 26, 2004 700+ words
...serum, of amyotrophic lateral sclerosis patients due to microglial activation. "Autopsy studies and animal experiments suggest that...amyotrophic lateral sclerosis: Further evidence for microglial activation in neurodegeneration. J Neuroimmunol, 2003;144...
- Silymarin protects dopaminergic neurons by inhibiting microglial activation.
- Newspaper article from: Immunotherapy Weekly February 19, 2003 700+ words
2003 FEB 19 - (NewsRx.com & NewsRx.net) -- "An inflammatory response in the central nervous system mediated by activation of microglia is a key event in the early stages of the development of neurodegenerative diseases. Silymarin is a polyphenolic flavanoid derived from milk thistle that has
- New theory emerges for nicotine's protective effect on the brain.
- Newspaper article from: Biotech Week April 7, 2004 700+ words
...neuroscientists at the University of South Florida (USF) College of Medicine has presented...cells known as microglia. Chronic microglial activation is a sign of brain inflammation that...to which nicotine binds to block microglial activation. "We propose that nicotine's...
- The South Florida Technology Alliance Releases Survey Findings.
- Press release article from: Business Wire January 14, 2004 700+ words
...Funding for Technology Interests The South Florida Technology Alliance released today...gauging the strengths and weaknesses of South Florida as a place for technology companies...because of its geographic proximity to South Florida and holds much potential once the economies...
- Spotlight: South Florida.(demographic changes may effect 2008 presidential...
- Magazine article from: Florida Trend Goodkin, Lewis M. January 1, 2001 700+ words
...but population dynamics in the three south Florida counties of Miami-Dade, Broward...elections will continue to exist, with south Florida continuing to provide the primary base...statewide. In the 2000 election, south Florida gave Al Gore a 365,000-vote margin...
- South Florida Manufacturing Association Encourages Businesses to Buy Local.
- Newspaper article from: Knight Ridder/Tribune Business News September 6, 2002 700+ words
By Marcia Heroux, South Florida Sun-Sentinel Knight Ridder...out about what it makes? The South Florida Manufacturing Association has...the theme, "Do You Buy/Sell South Florida?" The idea is to get South Florida...
