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Prostacyclin plays a pivotal role in normal and dysfunctional menstruation.
2004 APR 1 - (NewsRx.com & NewsRx.net) -- Prostacyclin plays a pivotal role in normal and dysfunctional menstruation.
"Prostacyclin (PGI[subscript]2) synthesis and function in the human uterus has been implicated in the regulation of the process of normal and dysfunctional menstruation. PGI[subscript]2 synthesis is elevated during normal menstruation and is also associated with blood loss in women who suffer from heavy menses. This study was designed to outline further the role of PGI[subscript]2 in menstruation by investigating the temporal pattern and site of expression of prostaglandin I synthase (PGIS) and the prostacyclin receptor (IP receptor) in the non-pregnant human endometrium across the menstrual cycle," scientists writing in the journal Reproduction report.
"Quantitative reverse transcriptase-polymerase chain reaction (RT-PCR) demonstrated increased expression of PGIS and IP receptor during the menstrual phase of the cycle compared with all other phases (p
"Functionality of the IP receptor in the human endometrium was assessed by measuring cAMP generation following treatment with 100 nmol l[superscript]-1 of the PGI[subscript]2 analogue, iloprost. cAMP generation was significantly higher in endometrial tissue collected during the proliferative compared with the secretory phase of the menstrual cycle (p
"In conclusion, this study has confirmed increased expression and signaling of PGIS and IP receptor during the menstrual phase and outlines a ...
- Prostacyclin plays a pivotal role in normal and dysfunctional menstruation.
- Newspaper article from: Health & Medicine Week March 29, 2004 700+ words
...normal and dysfunctional menstruation. "Prostacyclin...normal and dysfunctional menstruation. PGI[subscript...receptor (IP receptor) in the...PGIS and IP receptor during the...normal and dysfunctional menstruation," scientists...
- Joint TRA-418 receptor antagonist, agonist function increase antiplatelet...
- Newspaper article from: Cardiovascular Week December 29, 2003 700+ words
...functions of TP-receptor antagonist, IP-receptor agonist make it a better antiplatelet...receptor antagonist and prostacyclin (IP)-receptor agonist properties)," investigators...expression, and platelet aggregation. The IP-receptor agonist beraprost sodium inhibited platelet...
- Study data from Y.J. Lai and colleagues update understanding of pulmonary...
- Newspaper article from: Biotech Week August 27, 2008 700+ words
...binding to the prostacyclin receptor (IP receptor)," scientists in Bad Nauheim, Germany...hypertension have decreased expression of the IP receptor in the remodeled pulmonary arterial...prostanoid receptors other than the IP receptor are involved in signal transduction...
- Reports outline gastroenterology study findings from Josai University.
- Newspaper article from: Biotech Week July 1, 2009 700+ words
...abolished by treatment with a specific IP-receptor antagonist, CAY10441 (10(-9...Hepatocyte mitogenesis induced by the IP-receptor agonists was almost completely blocked...mitogenesis. Furthermore, treatment with the IP-receptor agonists significantly increased the...
- Reports on angiology findings from E. Gomez and co-researchers provide new...
- Newspaper article from: Biotech Week December 17, 2008 700+ words
...relaxations were inhibited by CAY-10441 (IP receptor antagonist). The relaxations to forskolin...in platelets from WKY and SHR, the IP receptor-dependent antiaggregant response is...concluded: "This dysfunction of the IP receptor is only partially explained by a general...
- Studies from Nippon Shinyaku Co., Ltd. provide new data on pulmonary...
- Newspaper article from: Biotech Week November 5, 2008 700+ words
...nonprostanoid prostacyclin receptor (IP receptor) agonist prodrug. In a rat model of...304, is much more selective for the IP receptor than are the prostacyclin analogs beraprost...SPA vasodilation resulting from their IP receptor agonism. Endothelium removal markedly...
- Findings from Johns Hopkins University broaden understanding of angiology.
- Newspaper article from: Blood Weekly December 18, 2008 700+ words
...researchers concluded: "The results establish a role for the IP receptor in protecting pyramidal hippocampal neurons after this global ischemic model and suggest that IP receptor agonists could be developed to prevent delayed pyramidal neuronal...
- NewCo News: Novartis Deal Brings Synosia Its Sixth CNS Compound.
- Magazine article from: BIOWORLD Today November 3, 2009 700+ words
...cognitive disorders; SYN-115 a selective A2A receptor inhibitor for Parkinson's disease and drug dependency; SYN-116, an IP-receptor inhibitor for acute and postoperative pain; and SYN-117, a selective dopamine a-hydroxylase inhibitor for Parkinson...
