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Immature myeloid DCs predominant in umbilical cord blood.
2004 APR 1 - (NewsRx.com & NewsRx.net) -- Immature myeloid DCs are predominant in umbilical cord blood from healthy newborns.
"It has been suggested lately that some types of antigen presenting cells-myeloid dendritic (DC-1) cells can differentiate the immune response towards Th1 type immunity, whereas lymphoid cells (DC-2) can stimulate Th2 type immunity," immunologists in Poland explained. "It has been observed that neonates are deficient in Th1 response."
D. Darmochwal-Kolarz and colleagues at the University of Lublin conducted a study "to estimate the proportions of immature myeloid (CD1c) and lymphoid (BDCA-2+, BDCA-4) dendritic cells and the CD1c+:BDCA-2+ cell ratio in cord blood of healthy neonates in comparison with dendritic cells of healthy adults."
"Thirty healthy neonates born from normal pregnancies and 30 healthy adults were included in the study," they wrote in the journal Immunology Letters. "The dendritic cells were isolated from cord and peripheral blood, stained with anti-CD1c, anti-BDCA-2, anti-BDCA-4, anti-CD123 and anti-CD19 monoclonal antibodies and estimated using flow cytometry."
"The percentage of CD1c+ dendritic cells in cord blood of healthy newborns did not differ significantly when compared to those in peripheral blood of healthy adults," test results revealed. "The percentages of cord blood BDCA-2+ and BDCA-4+ dendritic cells of neonates were significantly ...
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Source: HighBeam Research, Immature myeloid DCs predominant in umbilical cord blood.