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2004 APR 1 - (NewsRx.com & NewsRx.net) -- Propylthiouracil is preferred therapy for pregnant women with thyroid disease.
According to a study from France, "first cause of hyperthyroidism among women of childbearing age, Graves' disease raises the risk of maternal and fetal complications, including eclampsia, cardiac failure, abortion, prematurity, fetal death, all of which can be avoided if maternal hyperthyroidism is closely controlled."
"The risk of transplacental hyperthyroidism has been shown to correlate to the titer of anti-thyroid stimulating hormone (TSH) receptor antibodies and has to be evaluated not only in women treated for Graves' disease during pregnancy, but also in women who have previously received radioiodine treatment or undergone surgery for Graves' disease: TSH-receptor antibodies may indeed remain at a high level several years after initial treatment. Both methimazole and propylthiouracil are equally effective to restore maternal euthyroidism," wrote C. Bournaud and colleagues, Lyon-South Hospital Center, Endocrinology Service.
"Accumulation of case-reports relating congenital malformations (mostly aplasia cutis, but in some ...
Source: HighBeam Research, Propylthiouracil is preferred therapy for pregnant women with thyroid...