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Hepatic infiltration of leukemia cells leads to non-alcoholic steatohepatitis.
2004 APR 1 - (NewsRx.com & NewsRx.net) -- Hepatic infiltration of leukemia cells leads to non-alcoholic steatohepatitis.
According to a study from Japan, "a 54-yr-old female having chronic neutrophilic leukemia (CNL) associated with severe liver injury is presented. Physical examination on admission showed severe jaundice, hepatosplenomegaly, massive ascites, and pretibial edema."
"Complete blood count showed a hemoglobin level of 9.1 g/dL, platelet count of 25.8 x 10[superscript]4/microliter, and white blood cell count of 36.6 x 10[superscript]3)/microliter with 89.7% neutrophils. Blood chemistry showed hyperbilirubinemia (21.9 mg/dL) with normal transaminase levels. There was no abnormality in serum cholesterol, triglyceride, or glucose levels. Neutrophil alkaline phosphatase activity was significantly elevated. Bone marrow aspiration showed myeloid hyperplasia with normal karyotype," wrote C. Yoshida and colleagues, University of Tsukuba, Institute of Clinical Medicine.
"Rearrangement of the bcr/abl was not detected by either polymerase chain reaction or fluorescence in situ hybridization. Human androgen receptor gene assay (HUMARA) of the bone marrow cells showed clonal proliferation of neutrophils. The patient was diagnosed as having CNL."
"To evaluate the pathogenesis of the liver injury, a needle biopsy was performed, which showed steatohepatitis with infiltration of neutrophils. As the patient had no history of alcohol abuse, a diagnosis of non-alcoholic steatohepatitis (NASH) ...
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Source: HighBeam Research, Hepatic infiltration of leukemia cells leads to non-alcoholic...