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Tumor angiogenesis has no predictive value for epithelial ovarian cancer.
2004 APR 1 - (NewsRx.com & NewsRx.net) -- Tumor angiogenesis has no predictive value for epithelial ovarian cancer.
According to scientists in Turkey, "we aimed to evaluate the prognostic significance of microvessel density (MVD), vascular endothelial growth factor (VEGF), and transforming growth factor beta (TGF-beta), as well as to find out the relationship between MVD, and VEGF and TGF-beta in epithelial ovarian cancer (EOC). Surgical specimens of 47 patients with stage I-IV primary EOC, who underwent extended surgical staging according to FIGO, were investigated. Five-micrometer thick tissue sections were immunostained with antibody to factor VIII-related antigen, and MVD was assessed at three separate areas of x200 magnification."
"Expressions for VEGF and TGF-beta were evaluated by immunohistochemical staining using related monoclonal antibodies. Results were correlated with clinicopathologic factors and survival. We did not find any correlation between MVD and clinicopathologic factors, or patient survival. Similarly, there was no association between the degree of VEGF staining and survival or clinicopathologic factors, except preoperative ascites volume, which was higher in patients showing moderate and intense VEGF staining than those with weak VEGF staining (p=0.052)," reported M. Sonmezer and colleagues, Ankara University, Tip Fak.
"The expression of TGF-beta was ...
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...human ovarian cancer - epithelial ovarian cancer. The mouse model provides...her colleagues develop epithelial ovarian cancer in both ovaries. This...transgenic animals that develop epithelial ovarian cancer that spreads to the peritoneal...
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