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Steroid hormones are strong regulators of vaginal tissue contractility.
2004 APR 1 - (NewsRx.com & NewsRx.net) -- Steroid hormones are strong regulators of vaginal tissue contractility.
"The role of steroid hormones in regulating vaginal smooth muscle contractility was investigated. Rabbits were kept intact or ovariectomized. After 2 weeks, animals were continuously infused with vehicle or supraphysiological levels of testosterone (100 microgram/day), or estradiol (200 microgram/day), for an additional 2 weeks," scientists in the United States report.
"The distal vaginal tissue was used to assess contractility in organ baths and changes in tissue structure were assessed by histology. Ovariectomized animals infused with vehicle exhibited significant atrophy of the muscularis and decreased epithelial height, resulting in thinning of the vaginal wall. Estradiol infusion increased epithelial height, comparable to that of intact animals, but only partially restored the muscularis layer," said N.N. Kim and colleagues, Boston University, School of Medicine.
"In contrast, testosterone infusion completely restored the muscularis layer, but only partially restored the epithelial height. In vaginal tissue strips contracted with norepinephrine and treated with bretylium, electrical field stimulation (EFS) caused frequency-dependent relaxation that was slightly attenuated with vehicle, significantly inhibited with estradiol and significantly enhanced with testosterone."
"Vasoactive intestinal polypeptide ...
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Source: HighBeam Research, Steroid hormones are strong regulators of vaginal tissue...