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X-linked gene elements leave women vulnerable to primary biliary cirrhosis.
2004 APR 1 - (NewsRx.com & NewsRx.net) -- X-linked gene elements leave women vulnerable to primary biliary cirrhosis.
"The mechanisms that cause the female predominance of primary biliary cirrhosis (PBC) are uncertain, but the X chromosome includes genes involved in immunological tolerance. We assessed the rate of X monosomy in peripheral white blood cells from 100 women with PBC, 50 with chronic hepatitis C, and 50 healthy controls, by fluorescence in-situ hybridization," wrote P. Invernizzi and colleagues, University of Milan, San Pablo School of Medicine.
"Frequency of X monosomy increased with age in all groups, but was significantly higher in women with PBC than in controls (p
"We suggest that haploinsufficiency for specific X-linked genes leads to female susceptibility to PBC," researchers concluded.
Invernizzi and colleagues published their study in Lancet ...
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