AccessMyLibrary provides FREE access to over 30 million articles from top publications available through your library.
Create a link to this page
Copy and paste this link tag into your Web page or blog:
The VEGFR 2 inhibitor SU1498 stimulates ERK kinase accumulation and inhibition.
2004 APR 1 - (NewsRx.com & NewsRx.net) -- The VEGFR 2 inhibitor SU1498 stimulates ERK kinase accumulation and inhibition.
"SU1498, an inhibitor of vascular endothelial growth factor receptor 2, has been used successfully to study the physiological manifestations of receptor functions. Here we report that in addition to its anti-receptor activity, SU1498 stimulates accumulation of phosphorylated extracellular regulated kinases (ERKs) in human umbilical vein endothelial cells and in human aortic endothelial cells in a manner that is dependent on the functioning of the upstream components of the MAPK pathway, B-Raf, and MEK kinases," according to scientists in the United States.
"The enhanced accumulation of phospho-ERKs is observed only in cells that have been stimulated with sphingosine 1-phosphate or protein growth factors; SU1498 by itself is ineffective," noted G. Boguslawski and colleagues, Indiana University, School of Medicine.
"We show that the inhibitor acts by blocking the kinase activity of phospho-ERK both in a direct assay and in immunoprecipitates from cells treated ...
- Data on biological chemistry described by researchers at Johns Hopkins...
- Newspaper article from: Proteomics Weekly January 5, 2009 700+ words
Fresh data on biological chemistry are presented in the report...States report (see also Biological Chemistry). "Two of these proteins...University, Department of Biological Chemistry. The researchers concluded...
- Findings from Weizmann Institute of Science, Department of Biological Chemistry...
- Newspaper article from: Virus Weekly December 23, 2008 700+ words
...Institute of Science, Department of Biological Chemistry (see also Biological Chemistry). The researchers concluded: "This...of their research in the Journal of Biological Chemistry (The stability of the ternary interferon...
- Study findings from Johns Hopkins University, Department of Biological...
- Newspaper article from: Proteomics Weekly September 1, 2008 700+ words
...newly published data in Journal of Biological Chemistry. "O-Linked beta-N-acetylglucosamine...Hopkins University, Department of Biological Chemistry. The researchers concluded...published their study in the Journal of Biological Chemistry (Regulation of the O-linked beta...
- New biological chemistry study results reported from University of Arkansas.
- Newspaper article from: Chemicals & Chemistry June 19, 2009 700+ words
...scientists writing in the Journal of Biological Chemistry report. "Collagen binding efficiency...published their study in the Journal of Biological Chemistry (Unidirectional Binding of Clostridial...Helical Substrates. Journal of Biological Chemistry, 2009;284(16):10868-10876...
- New biological chemistry findings from University of Melbourne published.
- Newspaper article from: Chemicals & Chemistry July 3, 2009 700+ words
...scientists writing in the Journal of Biological Chemistry report. "To understand the in...published their study in the Journal of Biological Chemistry (Mice Lacking the Extracellular...Structure and Function. Journal of Biological Chemistry, 2009;284(18):12020-12030...
- New biological chemistry data have been reported by A. Hernandez and co-authors.
- Newspaper article from: Chemicals & Chemistry July 31, 2009 700+ words
...research published in the Journal of Biological Chemistry, "Mutants of the plant cation...published their study in the Journal of Biological Chemistry (Mutants of the Arabidopsis thaliana...TARGET FOR SALT TOXICITY. Journal of Biological Chemistry, 2009;284(21):14276-14285...
- New biological chemistry study findings have been published by scientists at...
- Newspaper article from: Chemicals & Chemistry July 31, 2009 700+ words
...research published in the Journal of Biological Chemistry, "Talin is a large flexible rod...published their study in the Journal of Biological Chemistry (The Structure of an Interdomain...Regulates Talin Activity. Journal of Biological Chemistry, 2009;284(22):15097-15106...
- New biological chemistry research from University of Helsinki outlined.
- Newspaper article from: Chemicals & Chemistry July 17, 2009 700+ words
...scientists writing in the Journal of Biological Chemistry report. "The relative expression...published their study in the Journal of Biological Chemistry (Coexpression and Heteromerization...Isoforms in Neonatal Brain. Journal of Biological Chemistry, 2009;284(20):13696-13704...