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Progestins mitigate thrombotic risk of contraceptive estrogens.
2004 APR 1 - (NewsRx.com & NewsRx.net) -- Progestins mitigate the thrombotic risk of contraceptive estrogens.
"A plausible mechanism to explain thrombotic risk differences associated with the use of second- and third-generation oral contraceptives (OCs), particularly in carriers of factor V[subscript]Leiden, is still lacking. In a double-blind trial, 51 women without and 35 women with factor V[subscript]Leiden were randomized to either a second- (30 microgram ethinylestradiol/150 microgram levonorgestrel) or third- (30 microgram ethinylestradiol/150 microgram desogestrel) generation OC. After two cycles of use and a wash-out of two cycles, the participants continued with the corresponding progestagen-only preparation," scientists in the Netherlands report.
"Hemostatic variables that probe the activity of the anticoagulant protein C system were determined," said Jeanet M. Kemmeren and collaborators at the University of Utrecht, University of Amsterdam, and Maastricht University. "Compared with levonorgestrel, desogestrel-containing OCs significantly decreased protein S and increased activated protein C (APC) resistance in both groups. OCs with desogestrel had the most pronounced effects in carriers of factor V[subscript]Leiden. Progestagen-only preparations caused changes of anticoagulant parameters opposite to those of combined OCs, which in a number of cases were more pronounced ...
- Elevated Plasma factor VIII Levels Associated with Increased Thrombotic Risk.
- Newspaper article from: Blood Weekly March 29, 1999 700+ words
...findings suggest. T. Kawasaki and colleagues investigated the thrombotic risk associated with elevated plasma levels of clotting factor...elevated plasma FVIII levels are associated with an increased thrombotic risk, also in arteries," wrote Kawasaki et al. The corresponding...
- Bio-Rad Thrombotic Risk Assay Receives FDA Clearance.
- Press release article from: PR Newswire February 9, 2000 700+ words
HERCULES, Calif., Feb. 8 /PRNewswire/ -- Bio-Rad Laboratories, Inc. (Amex: BIO.A, BIO.B) announced today that its Homocysteine by HPLC assay has received (December 21, 1999) marketing clearance from the United States Food and Drug Administration. The measurement of homocysteine levels is used in
- The combination of high serum albumin, fibrinogen, Ig may pose a thrombotic...
- Newspaper article from: Medical Devices & Surgical Technology Week January 18, 2004 700+ words
2004 JAN 18 - (NewsRx.com & NewsRx.net) -- Immunoglobulin therapy may only pose a risk of thrombosis if there are high levels of fibrinogen, albumin, and immunoglobin (Ig), but not if any is lower. "Therapeutic administration of Ig has the potential to precipitate thrombotic events. This
- Investigators at Medical University of Vienna, Department of Internal Medicine...
- Magazine article from: Women's Health Weekly November 20, 2008 700+ words
...Oral contraceptives increase the thrombotic risk in women with factor V Leiden...article was prepared by Women's Health Weekly editors from staff and other reports. Copyright 2008, Women's Health Weekly via NewsRx.com.
- Combined oral contraceptives affect activated protein C resistance.
- Magazine article from: Women's Health Weekly November 25, 2004 700+ words
...Previous data reported higher thrombotic risk in women using third-generation...article was prepared by Women's Health Weekly editors from staff and other reports. Copyright 2004, Women's Health Weekly via NewsRx.com & NewsRx...
- High levels of anxiety may affect coagulation of blood.
- Newspaper article from: Mental Health Weekly Digest December 13, 2004 700+ words
...individuals to an elevated arterial thrombotic risk. The authors, writing in the...article was prepared by Mental Health Weekly Digest editors from staff and...reports. Copyright 2004, Mental Health Weekly Digest via NewsRx.com &...
- Obesity increases the risk of venous thrombosis.
- Magazine article from: Women's Health Weekly May 8, 2003 700+ words
...and acquired. It is unclear whether obesity affects thrombotic risk in unselected patients," scientists writing in the...Contraception. This article was prepared by Women's Health Weekly editors from staff and other reports.
- Patch or gel formulations may cause fewer venous blood clots.
- Magazine article from: Women's Health Weekly August 28, 2003 700+ words
...transdermal ERT might be safer than oral ERT with respect to thrombotic risk." For more information, contact Dr. Pierre Yves...inserm.fr. This article was prepared by Women's Health Weekly editors from staff and other reports.