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Polo-like kinase 1 is a viable target for the treatment of prostate cancer.
2004 APR 1 - (NewsRx.com & NewsRx.net) -- Polo-like kinase 1 is a viable target for the treatment of prostate cancer.
"Second only to skin cancer, cancer of the prostate gland (CaP) is the most commonly occurring cancer in American men. Existing treatment approaches and surgical intervention have been unable to effectively manage this dreaded cancer; therefore, efforts are ongoing to explore novel targets and strategies for the management of CaP. A complete understanding of the genetic control of the processes of cellular proliferation and programmed cell death, or apoptosis, may provide the basis for the rational design of novel therapeutic strategies against CaP," scientists writing in the FASEB Journal report.
"Key regulators for the mitotic progression in mammalian cells are the polo-like kinases (Plks). The activity of Plk1 is elevated in tissues and cells with a high mitotic index, including cancer cells. An increasing body of evidence suggests that the level of Plk1 expression has prognostic value for predicting outcomes in patients with some cancers such as lung cancer, squamous cell carcinomas of the head and neck, melanomas, and ovarian and endometrial carcinomas," according to N. Ahmad and colleagues, University o Wisconsin, Medical Science Center.
"However, the role of Plk1 in CaP is not known. Here, a hypothesis is put forward that Plk1 plays a critical role in the development ...
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...Cohen, A.D.; Boyer, J.D.; Weiner, D.B. According to the authors' abstract of an article published in Faseb Journal, "Genetic immunization, also known as DNA or polynucleotide immunization, is a novel strategy for vaccine development...
- Polo-like kinase 1 is a viable target for the treatment of prostate cancer.
- Newspaper article from: Cancer Gene Therapy Week March 29, 2004 700+ words
...published their study in FASEB Journal (Polo-like kinase...for the treatment of prostate cancer. FASEB J, 2004...The publisher of the FASEB Journal can be contacted at...Drug Development and Prostate Cancer. This article was...
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...catalogue. Stakeholder Insight: Prostate Cancer - Hormone-refractory patients still...p073694/Stakeholder-Insight-Prostate -Cancer---Hormone-refractory-patients...standard for hormone-refractory prostate cancer, many patients are still precluded...
