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Estrogen interacts with estrogen receptor and SP proteins to control VEGF.
2004 APR 1 - (NewsRx.com & NewsRx.net) -- Estrogen interacts with estrogen receptor and SP proteins to control VEGF.
"Vascular endothelial growth factor (VEGF) is expressed in multiple hormone-dependent cancer cells/tumors. Treatment of ZR-75 breast cancer cells with 17beta-estradiol (E[subscript]2) induced a greater than four-fold increase of VEGF mRNA levels. ZR-75 breast cancer cells were transfected with pVEGF1, a construct containing a -2018 to +50 VEGF promoter insert, and E[subscript]2-induced reporter gene (luciferase) activity," scientists in the United States report.
"Deletion and mutation analysis of the VEGF gene promoter identified a GC-rich region (-66 to -47) which was required for E[subscript]2-induced transactivation of pVEGF5, a construct containing the minimal promoter (-66 to +54) that exhibited E[subscript]2 responsiveness," wrote M. Stoner and colleagues, Texas A&M University, Department of Veterinary Physiology and Pharmacology.
"Interactions of nuclear proteins from ZR-75 cells with the proximal GC-rich region of the VEGF gene promoter were investigated by electrophoretic mobility shift and chromatin immunoprecipitation assays. The results demonstrate that both Sp1 and Sp3 proteins bound the GC-rich motif (-66 to +47), and estrogen receptor alpha (ERalpha) interactions were ...
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Source: HighBeam Research, Estrogen interacts with estrogen receptor and SP proteins to control...