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New inoculations show promise.
2004 MAR 31 - (NewsRx.com & NewsRx.net) -- Tests of an experimental smallpox vaccine have produced encouraging results in monkeys and mice. The discovery may lead to an alternative for humans unable to receive current smallpox vaccines.
Monkeys treated with modified vaccinia virus Ankara (MVA) were immune to monkeypox, which is similar to smallpox in humans, reported Bernard Moss and colleagues at the U.S. National Institutes of Health in the March 11, 2004, issue of Nature. Monkeys that did not receive the treatment became severely ill after being exposed to monkeypox.
Monkeys were most resistant to the disease when treated with MVA and then with the existing smallpox vaccine Dryvax, the authors reported. This suggests that MVA could be used as a "prevaccine," to which Dryvax could be added in the event of a specific smallpox threat, or ...
- Second U.S. government MVA smallpox vaccine contract awarded.
- Newspaper article from: Vaccine Weekly November 10, 2004 700+ words
...attenuated smallpox vaccine, such as MVA, as part of its defense against...tender in due course. Acambis' MVA vaccine was recently granted...government supply contracts for an MVA stockpile. We are confident...This article was prepared by Vaccine Weekly editors from staff and other...
- First MVA Vaccine Cleared for Human Testing.(modified vaccinia...
- Newspaper article from: Vaccine Weekly October 4, 2000 700+ words
...Phase I testing of an MVA vaccine based on HIV...vaccinating with either DNA or MVA alone. These studies...article was prepared by Vaccine Weekly editors from staff and...reports. Copyright 2000, Vaccine Weekly via NewsRx.com.
- U.S. government grants patent for MVA-BN vaccine.
- Newspaper article from: Vaccine Weekly August 18, 2004 700+ words
...addition to covering the MVA-BN virus itself, the patent includes the use of MVA-BN as a smallpox vaccine...and extends to the use of MVA-BN as a vector technology...This article was prepared by Vaccine Weekly editors from staff and other...
- MVA ROP2 vaccinia virus is vaccine candidate for toxoplasmosis.
- Newspaper article from: Vaccine Weekly August 11, 2004 700+ words
...span of mice is increased in MVA ROP2 vaccinated annuals." "We conclude that MVA ROP2 vaccine can possibly...their study in Parasitology (MVA ROP2 vaccinia virus recombinant...This article was prepared by Vaccine Weekly editors from staff and other...
- MVA-HIV-1 nef vaccine elicits T-helper cell responses in HIV patients.
- Newspaper article from: Vaccine Weekly April 28, 2004 700+ words
...attenuated vaccinia-vir-us vector MVA is safe in HIV-1 infected...cell response elicited by MVA-nef vaccination provides a...Therapeutic vaccination with MVA-HIV-1 nef elicits Nef...This article was prepared by Vaccine Weekly editors from staff and other...
- DNA prime-MVA boost HIV vaccine tailored for eastern and central Africa.
- Newspaper article from: Vaccine Weekly September 1, 2004 700+ words
...immunogenicities of the pTHr.RENTA and MVA.RENTA vaccines in mice...Engineering RENTA, a DNA prime-MVA boost HIV vaccine tailored...This article was prepared by Vaccine Weekly editors from staff and other reports. Copyright 2004, Vaccine Weekly via NewsRx.com & NewsRx...
- Second Phase II Clinical Trial Of MVA-HPV-IL2 Vaccine Initiated.(Brief Article)
- Newspaper article from: Vaccine Weekly January 16, 2002 700+ words
...immune response in some patients. MVA-HPV-IL2 uses the MVA vector, a highly attenuated...of treating VIN3 patients with MVA-HPV-IL2 is to induce an efficient...This article was prepared by Vaccine Weekly editors from staff and other...
- Phase II Clinical Trial Of MVA-HPV-IL2 Initiated.(Brief Article)
- Newspaper article from: Vaccine Weekly December 19, 2001 700+ words
...cervical cancer patients with MVA-HPV-IL2 is to induce an...Phase I clinical trials of MVA-HPV-IL2 conducted in the...safety and tolerance profile of MVA-HPV-IL2, and provided evidence...This article was prepared by Vaccine Weekly editors from staff and other...