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Children with nephrotic syndrome have adequate response to influenza vaccine.

Vaccine Weekly

| March 31, 2004 | COPYRIGHT 2004 NewsRX. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan.  All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)Copyright

2004 MAR 31 - (NewsRx.com & NewsRx.net) -- Children with nephrotic syndrome have an adequate antibody response to influenza A vaccination.

"The aim of this study was to determine the antibody response to influenza vaccination in children with nephrotic syndrome (NS). Nineteen children with NS and 10 healthy controls were vaccinated with a 1999-2000 influenza vaccine. A dose of 0.25 mL was used for those under 6 years and 0.5 mL for those over 6 years. All children were given two doses with a month between each dose. Antibody titers were measured before vaccination and 1 month after vaccination in both groups and 6 months after vaccination in eight patients with NS," investigators in Turkey report.

"The proportion of subjects in the nephrotic group with protective antibody titers before immunization (10.5%) was significantly lower than the proportion at one (78.9%) and 6 months (87.5%) post vaccination," stated Hakan M. Poyrazoglu and colleagues at Erciyes University. "The mean concentration of specific IgG antibodies to influenza A in the NS group increased 6-fold at 1 month and ...

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