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HIV-neutralizing antibody fragment isolated from lupus library.
2004 MAR 31 - (NewsRx.com & NewsRx.net) -- An HIV-neutralizing lupus antibody fragment has been identified.
According to published research from the United States, a "single-chain fragment containing antibody V domains (scFv) isolated from a lupus antibody library displayed the ability to bind gp120 and the conserved gp120 determinant composed of residues 421-436."
"The scFv neutralized R5 and X4-dependent HIV-1 strains from clades B, C and D," reported S. Karle and coauthors at the University of Texas.
"The lupus repertoire may be useful as a source of neutralizing antibodies to HIV," the researchers concluded.
Karle and colleagues published their study in AIDS (Cross-clade HIV-1 ...
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