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HIV-1 Nef delivery to dendritic cells may stimulate immune response.
2004 MAR 31 - (NewsRx.com & NewsRx.net) -- Delivery of HIV-1 Nef to dendritic cells using an adenoviral vector shows promise as a method to induce an immune response against HIV-1.
"The Net gene is a major determinant of HIV-1 pathogenicity. Several immunomodulatory functions have been reported for Nef, including down-regulation of CD4 and class I MHC in T-lymphocytes, and the ability to enhance viral transmission from macrophages and dendritic cells (DC) to T-lymphocytes. In this study, HIV-1 (SF2 strain) Nef was expressed in human monocyte-derived dendritic cells, using an adenovirus based delivery system," researchers in England and the United States report.
"Nef expression resulted in decreased CD4 levels, but no change to class I MHC, and no impairment in the ability of DC to stimulate recall PPD responses, mixed leukocyte responses, or hepatitis B-specific CD8 responses," stated Luci P. Maccormac and collaborators at University College London in England and the University of Massachusetts in the U.S. "The adenovirus vector itself stimulated a strong recall CD4 response in all individuals tested, and also induced up-regulation of class I MHC, CD86 and CD40 on the dendritic ...
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