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CG motifs in virus-like particles induce cytotoxic T cell responses.
2004 MAR 31 - (NewsRx.com & NewsRx.net) -- Nonmethylated CG motifs packaged into virus-like particles induce protective cytotoxic T cell responses in the absence of systemic side effects.
According to a study from Switzerland, "DNA rich in nonmethylated CG motifs (CpGs) greatly facilitates induction of immune responses against co-administered antigens. CpGs are therefore among the most promising adjuvants known to date. Nevertheless, CpGs are characterized by two drawbacks."
"They have unfavorable pharmacokinetics and may exhibit systemic side effects, including splenomegaly," said Tazio Storni and collaborators at Cytos Biotechnology AG and the Paul Scherrer Institut. "We show in this study that packaging CpGs into virus-like particles (VLPs) derived from the hepatitis B core antigen or the bacteriophage Qbeta is a simple and attractive method to reduce these two problems."
"CpGs packaged into VLPs are resistant to DNase I digestion, enhancing their stability," reported the researchers. "In addition, and in contrast to free CpGs, packaging CpGs prevents splenomegaly in mice, without affecting their immunostimulatory capacity. In fact, vaccination with CpG-loaded VLPs was able ...
- CG motifs in virus-like particles induce cytotoxic T cell responses.
- Newspaper article from: Health & Medicine Week March 29, 2004 700+ words
...amp; NewsRx.net) -- Nonmethylated CG motifs packaged into virus-like...Switzerland, "DNA rich in nonmethylated CG motifs (CpGs) greatly facilitates...Journal of Immunology (Nonmethylated CG motifs packaged into virus-like...
- Leishmania antigen and ODN protect against L. donovani infection.
- Newspaper article from: Medical Letter on the CDC & FDA December 26, 2004 700+ words
...According to published research from India, "In this report, we investigated the effect of ODN containing immunostimulatory CG motifs as adjuvant with soluble antigen (SA) from Leishmania donovani. BALB/c mice were vaccinated with the soluble antigen with...
- EUROPEAN PATENT DISCLOSURES.
- Magazine article from: BIOWORLD Today October 26, 2000 700+ words
...50075 Neisseria therapeutics Siena, Italy Enhancing bactericidal activity of Neisseria antigens using oligonucleotides having CG motifs. Chugai EP 1 033 374 Sequence signal trap Tokyo Linking the secretory signal of the human mpl gene to a test DNA; for trapping...
