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IL-2-activated NK cells enhance effect of tumor vaccine in brain cancer.
2004 MAR 31 - (NewsRx.com & NewsRx.net) -- Intratumoral injection of IL-2-activated NK cells enhances the antitumor effect of intradermally injected paraformaldehyde-fixed tumor vaccine in a rat intracranial brain tumor model.
"Combined therapy with a fixed-tumor cell vaccine and intratumoral injection of INK cells induced strong tumor regression of rat glioma. Rat 9L glioma cells were inoculated into syngeneic male rats at the flank (subcutaneous tumor model) or at the basal ganglia of the right hemisphere (intracranial tumor model). Rats were intradermally injected three times with vaccine comprising fixed 9L cells, IL-2- and GMCSF-microparticles, and tuberculin prior to (protective studies) or after (therapeutic studies) challenge with live 9L cells," scientists writing in the journal Cancer Science report.
"In the protective studies, the vaccine alone achieved significant tumor growth inhibition and elongation off mean life span in both the subcutaneous and intracranial tumor models," stated Eiichi Ishikawa and collaborators at the University of Tsukuba and the Institute of Physical and Chemical Research (RIKEN). "No therapeutic effect was observed in the intracranial tumor model with the vaccine alone. However, intratumoral injection of rat INK cells strongly assisted the therapeutic effect of the vaccine in the brain tumor ...
- Tumor model established in HLA-A*0201 transgenic mice to test vaccines.
- Newspaper article from: Vaccine Weekly January 1, 2003 700+ words
...strategies, it is important to establish a tumor model in HLA-A*0201 transgenic mice...restricted epitopes. We used this tumor model to test the efficacy of two genetic...concluded that theirs "is the first tumor model that allows for the assessment of the...
- EntreMed's Panzem(R) Demonstrates Antitumor Activity in Brain Tumor Model.
- Press release article from: PR Newswire December 21, 2006 700+ words
...2ME2 or 2-methoxyestradiol), in an orthotopic brain tumor model. The results of the studies, conducted by EntreMed collaborators...histological evaluation in a preclinical orthotopic glioma tumor model, 2ME2 treatment resulted in a dose-dependent reduction...
- Escape of mammary cell senescence can be seen in murine mammary tumor model.
- Newspaper article from: Biotech Week June 9, 2004 700+ words
...Researchers discuss gene alterations observed in the murine mammary tumor model. "Human mammary epithelial cells emerge spontaneously from...scientists in the United States report. "In a mouse mammary tumor model, the spontaneous escape of senescence can be observed as...
- AVAX Technologies Announces Publication of Paper on the Anti-Metastatic...
- Press release article from: PR Newswire June 11, 2002 700+ words
...hapten-modified autologous tumor cell vaccine in an animal tumor model" in the journal Cancer Immunology Immunotherapy (2002...after removal of primary tumors in a mouse metastatic mammary tumor model compared to that of untreated animals. Furthermore, the...
- Tumor model traces deadly progression of cells.
- Newspaper article from: Genomics & Genetics Weekly March 28, 2003 700+ words
...scene at different stages of the disease, treatments can be tailored to the patient's stage of cancer progression. The tumor model constructed by Singh and his colleagues also should enable earlier diagnosis of oral cancer, which currently depend on the...
- Tumor model traces deadly progression of cells.(oral cancer model)
- Newspaper article from: Cancer Weekly March 25, 2003 700+ words
...scene at different stages of the disease, treatments can be tailored to the patient's stage of cancer progression. The tumor model constructed by Singh and his colleagues also should enable earlier diagnosis of oral cancer, which currently depend on the...
- Positive CoFactor results reported in pancreatic tumor model.
- Newspaper article from: Pharma Business Week July 26, 2004 700+ words
...announced statistically significant tumor inhibition and survival using CoFactor combination treatments in a pancreatic tumor model. Results were presented by Mark J. Cantwell, director of Preclinical Programs for Adventrx, on June 26 at the Pancreatic...
- Researchers study a chemotherapy-resistant neural crest tumor model.
- Newspaper article from: Biotech Week June 9, 2004 700+ words
2004 JUN 9 - (NewsRx.com & NewsRx.net) -- In a neural crest tumor model, researchers are developing promising ways of combating chemotherapy resistance. According to recent research from the United...