AccessMyLibrary provides FREE access to over 30 million articles from top publications available through your library.
Create a link to this page
Copy and paste this link tag into your Web page or blog:
IL-12 enhances immunity of Schistosoma mansoni fatty acid-binding protein.
2004 MAR 31 - (NewsRx.com & NewsRx.net) -- IL-12 enhances protective immunity in mice engendered by immunization with recombinant 14-kDa Schistosoma mansoni fatty acid-binding protein through an IFN-gamma and TNF-alpha dependent pathway.
"Herein, we tested the ability of IL-12 to enhance protection induced by recombinant Sm14 (rSml4). Mice immunization with three doses of 25 jig of rSml4 was able to induce 25% protection in mice against challenge. However, co-administration of exogenous IL-12 enhanced protective immunity engendered by rSm14 from 25 to 42.2%. Higher levels of IgG2a and TNF-alpha were observed in mice immunized with rSml4 plus IL-12 compared to animals vaccinated with rSml4 alone," scientists in Brazil report.
"Regarding other cytokines, significant amounts of IFN-gamma were measured in splenocyte culture supernatants of rSm14/IL-12 or rSm14 vaccinated mice and no IL-4 was detected," stated Cristina T. Fonseca and collaborators at the Federal University of Minas Gerais and the Oswaldo Cruz Foundation. "In an attempt to determine the role of IFN-gamma and TNF-alpha in IL-12 induced immunity, IFN-gamma and TNFR-p55 knockout mice were immunized with rSm 14/IL-12 and no protection was achieved. Therefore, protection induced by rSm 14/IL-12 was shown to ...
- The relationship between serum levels of total IgE, IL-18, IL-12, IFN-[gamma]...
- Magazine article from: Mediators of Inflammation Aral, Murat Arican, Ozer Gul, Mustafa Sasmaz, Sezai Kocturk, Sumeyra Alkis Kastal, Ummugulsum Ekerbicer, Hasan Cetin January 1, 2006 700+ words
...completely clarified yet. Serum levels of total IgE, IL-18, IL-12, IFN-[gamma] and the relationship between these parameters...the severity. Serum levels of total IgE, IL-18, IL-12, IFN-[gamma] and the relationship between these parameters...
- Induction of a soluble anti-HIV-1 factor (s) with IFN-[gamma], IL-10, and...
- Magazine article from: American Journal of Infectious Diseases Rodriguez, Jose W. Pagan, Nat O. Ocasio, Maria C. Rios, Zilka Cubano, Luis A. Boukli, Nawal M. Otero, Miguel Hunter, Robert Nair, Madhavan P. Rios-Olivares, Eddy October 1, 2007 700+ words
...associated with induction of IFN-[gamma], MIP-1[alpha...production, but inhibition of IL-10. Furthermore, this...activator (ATF-uPA), IL-16, antithrombin III...peroxiredoxin, TNF-[alpha], IL-13, IFN-[gamma]/[alpha...
- IFN-gamma induced products repress transcription of Th2-determining IL-4.
- Newspaper article from: Proteomics Weekly February 24, 2003 700+ words
...host immunity to pathogens. IL-4 and IFN-gamma are the signature cytokines...described. We show here that IFN-gamma directly suppresses IL-4 gene expression. IRF...published their study in Immunity (IFN-gamma represses IL-4 expression via IRF-1...
- G-CSF promotes generation of regulatory DC through IL-10 and IFN-alpha...
- Newspaper article from: Health & Medicine Week July 26, 2004 700+ words
...regulatory dendritic cells through IL-10 and IFN-alpha induction. "We have recently...which contained high amounts of IL-10 and IFN-alpha. Similar to incompletely...10. Finally, neutralization of IL-10 and IFN-alpha contained in post-G serum...
- COLD-FX augments Con-A-induced splenic IL-2 and IFN-gamma production.
- Newspaper article from: Biotech Week May 12, 2004 700+ words
...induced splenic production of IL-2 and IFN-gamma in a murine model. "A...significantly increased Con-A-induced IL-2 and IFN-gamma productions in spleen cells...Panax quinquefolium) enhances IL-2 and IFN-gamma productions in murine spleen...
- CGRP down-regulates IL-2 and IFN-gamma and up-regulates IL-4 production.
- Newspaper article from: Biotech Week July 21, 2004 700+ words
...Calcitonin gene-related peptide down-regulates IL-2 and IFN-gamma and up-regulates IL-4 production. "The signal transduction of...related peptide (CGRP) down-regulates IL-2 and IFN-gamma production and up-regulates IL-4...
- IFN-gamma production during RSV infection is not associated with IL-12 or -18.
- Newspaper article from: Drug Week July 2, 2004 700+ words
...76.9%) subjects tested, but the IFN gamma-inducing cytokines interleukin (IL)-12 and IL-18 were detectable in...gamma," test results revealed. "IL-18, but neither IFN-gamma nor IL-12 was found in significantly greater...
- IFN-alpha priming results in a gain of proinflammatory function by IL-10.
- Newspaper article from: Biotech Week July 21, 2004 700+ words
...low concentrations of IFN-alpha diminished the ability of IL-10 to suppress TNF...IL-10, leading to IL-10 activation of expression of IFN-gamma-inducible...STAT1 was required for IL-10 activation of IFN-gamma-inducible protein...
Source: HighBeam Research, IL-12 enhances immunity of Schistosoma mansoni fatty acid-binding...