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Lentiviral vector encoding NY-ESO-1 induces effective CTL response.
2004 MAR 31 - (NewsRx.com & NewsRx.net) -- Intravenous injection of a lentiviral vector encoding NY-ESO-1 induces an effective cytotoxic T lymphocyte (CTL) response.
"Lentiviral vectors can efficiently transduce a variety of nondividing cells, including antigen-presenting cells (APCs). We assessed the immunogenicity of a lentiviral vector encoding the melanoma antigen NY-ESO-1 in HLA-A2 transgenic mice. Direct iv injection of NY-ESO-1 lentivirus induced NY-ESO-1[subscript]157-165-specific CD8+ cells, detected ex vivo with an A2/H-2K[superscript]b chimeric class I tetramer. These NY-ESO-1(157-165-specific) CD8+ cells could be expanded by boosting with an NY-ESO-1 vaccinia virus and could kill NY-ESO-1[subscript]157-165 peptide-pulsed targets in vivo," scientists writing in the Journal of Immunology report.
"Such direct lentiviral vector injection was similar in potency to the injection of in vitro-transduced dendritic cells (DC)," said Michael J. Palmowski and collaborators at John Radcliffe Hospital in Oxford and University College in London. "In addition, human monocyte-derived DC transduced by the NY-ESO-1 lentivirus stimulated an ...
- Lentiviral vector encoding NY-ESO-1 induces effective CTL response.
- Newspaper article from: Cancer Weekly March 30, 2004 700+ words
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Source: HighBeam Research, Lentiviral vector encoding NY-ESO-1 induces effective CTL response.