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Hepatitis E virus-like particles protect monkeys against HEV infection.
2004 MAR 31 - (NewsRx.com & NewsRx.net) -- Oral administration of recombinant hepatitis E virus-like particles protected cynomolgus monkeys against HEV infection.
According to recent research published in the journal Vaccine, "Hepatitis E virus (HEV) is an important causative agent of enterically transmitted hepatitis. Successful vaccine development is crucial in controlling global HEV infection. HEV capsid protein, with 111 amino acids truncated at the N-terminus, was efficiently expressed in the baculovirus expression system."
"Expressed protein spontaneously assembled into virus-like particles (VLPs) and was released into culture medium," reported Tian-Cheng Li and collaborators at the National Institute of Infectious Diseases in Tokyo. "When cynomolgus monkeys were orally inoculated with 10 mg of purified rHEV VLPs, serum IgM, IgG, and IgA responses were observed. All these antibody responses were obtained without adjuvants. When the monkeys were challenged with native HEV by intravenous injection, they were protected against infection or developing ...
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Source: HighBeam Research, Hepatitis E virus-like particles protect monkeys against HEV...