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Poor prognosis for depression linked to an autoimmune thyroid condition.
2004 MAR 31 - (NewsRx.com & NewsRx.net) -- Whether depression is linked to having an underactive thyroid gland has been debated for many years. New research suggests that some patients with depression may be suffering from a subtle autoimmune thyroid condition, which could hinder their recovery.
The study also suggests that physicians could use indicators of thyroid function to predict patients' responsiveness to antidepressants. As inpatients with depression often undergo routine thyroid tests, the data that physicians would need to create such a prediction are likely to be available to them already.
Researchers from Greece studied 30 patients suffering from major depression, and 60 healthy people as controls. Each patient was examined by two psychiatric experts, who assessed their condition during a structured interview. The researchers then tested the thyroid function of all the volunteers. Their findings were published in BMC Psychiatry March 15, 2004.
Although the levels of the thyroid function indicators FT3, FT4 and TSH, fell inside the normal range for all the people studied, suffering from depression appeared to increase the level of thyroid binding inhibitory immunoglobulins in the blood of some patients. High levels of these immunoglobulins can subtly inhibit the function of the thyroid gland.
The authors wrote, "Although thyroid dysfunction is not common in depression there is evidence suggesting the presence of an underlying autoimmune process affecting the thyroid gland in depressive patients. ... The finding ...
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Source: HighBeam Research, Poor prognosis for depression linked to an autoimmune thyroid...