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Altering conditions of DNA immunization allows control of immune response.
2004 MAR 31 - (NewsRx.com & NewsRx.net) -- Altering the cellular localization of expressed protein and the immunization route in DNA immunization allows manipulation of the immune response.
According to published research from the United States, "DNA immunization by intramuscular (IM) injection induces Th1 responses, whereas gene gun (GG) immunization into the skin stimulates Th2 responses. Three ovalbumin (OVA) cDNA constructs, in which OVA is cytoplasmic (CYT), secreted (SECR), or transmembrane (TM), were compared in immunization studies using intramuscular injection or biolistic bombardment of the skin."
"Gene gun immunization with OVA-CYT or OVA-TM led to strong OVA-specific CTL responses, but not following OVA-SECR immunization," reported Penelope A. Morel and colleagues at the University of Pittsburgh. "In contrast, intramuscular immunization with OVA-SECR or OVA-TM led to potent CTL while immunization with OVA-CYT was ineffective. OVA-specific antibodies were detected following GG immunization with all three constructs, whereas only the OVA-SECR construct induced antibody production following intramuscular immunization. ...
- Altering conditions of DNA immunization allows control of immune response.
- Newspaper article from: Genomics & Genetics Weekly April 2, 2004 700+ words
...immunization route in DNA immunization allows manipulation...United States, "DNA immunization by intramuscular...Three ovalbumin (OVA) cDNA constructs...whereas only the OVA-SECR construct...and the route of DNA immunization." Morel and her...
- DNA immunization technology patents licensed. (Dynavax Technologies Corp.'s...
- Newspaper article from: Vaccine Weekly January 19, 1998 700+ words
...other firm's patented technology for DNA immunization with its own in developing products...to certain Vical patents covering DNA immunization for Dynavax's use in the fields...to certain Dynavax patents covering DNA immunization through the skin for use in the fields...
- DNA Immunization With Minigenes: Low Frequency of Memory Cytotoxic T...
- Newspaper article from: Immunotherapy Weekly June 29, 1998 700+ words
...Campbell, I.L.; Whitton, J.L. "DNA Immunization With Minigenes: Low Frequency of...previously demonstrated the utility of DNA immunization using plasmids encoding full-length...the effectiveness of minigenes in DNA immunization. We find that DNA immunization with...
- DNA Immunization Produces Anti-Major Histocompatibility Complex Antibody...
- Newspaper article from: AIDS Weekly September 11, 2000 700+ words
...2000 SEP 11 - (NewsRx.com) -- DNA immunization with major histocompatibility complex...studies, the researchers showed that DNA immunization with class I and class II MHC-encoding...animals. "These studies show that DNA immunization with MHC-encoding vectors can indeed...
- Infection spread inhibited by DNA immunization with C. trachomatis pgp3...
- Newspaper article from: Vaccine Weekly April 16, 2003 700+ words
...experiments with C3H/HeN mice, DNA immunization with the pgp3 gene of "Chlamydia...reported, "Overall, the pgp3-DNA immunization prevented salpinx infection in 94...Donati's group said. "Pgp3 DNA immunization induced both humoral and mucosal anti...
- Infection spread inhibited by DNA immunization with C. trachomatis pgp3...
- Magazine article from: Women's Health Weekly April 17, 2003 700+ words
...experiments with C3H/HeN mice, DNA immunization with the pgp3 gene of "Chlamydia...reported, "Overall, the pgp3-DNA immunization prevented salpinx infection in 94...Donati's group said. "Pgp3 DNA immunization induced both humoral and mucosal anti...
- DNA immunization achieved with plasmids expressing hCG beta-chimeras.
- Newspaper article from: Biotech Week August 18, 2004 700+ words
...NewsRx.com & NewsRx.net) -- DNA immunization was achieved with plasmids expressing...immunotherapy. We have explored the use of DNA immunization with the aim of improving the immunogenicity...following hCGp immunization, at least for DNA immunization, is related to the amount of ...
- DNA Immunization Produces Anti-Major Histocompatibility Complex Antibody...
- Newspaper article from: Gene Therapy Weekly September 14, 2000 700+ words
...2000 SEP 14 - (NewsRx.com) -- DNA immunization with major histocompatibility complex...studies, the researchers showed that DNA immunization with class I and class II MHC-encoding...animals. "These studies show that DNA immunization with MHC-encoding vectors can indeed...
