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Altering conditions of DNA immunization allows control of immune response.
2004 MAR 31 - (NewsRx.com & NewsRx.net) -- Altering the cellular localization of expressed protein and the immunization route in DNA immunization allows manipulation of the immune response.
According to published research from the United States, "DNA immunization by intramuscular (IM) injection induces Th1 responses, whereas gene gun (GG) immunization into the skin stimulates Th2 responses. Three ovalbumin (OVA) cDNA constructs, in which OVA is cytoplasmic (CYT), secreted (SECR), or transmembrane (TM), were compared in immunization studies using intramuscular injection or biolistic bombardment of the skin."
"Gene gun immunization with OVA-CYT or OVA-TM led to strong OVA-specific CTL responses, but not following OVA-SECR immunization," reported Penelope A. Morel and colleagues at the University of Pittsburgh. "In contrast, intramuscular immunization with OVA-SECR or OVA-TM led to potent CTL while immunization with OVA-CYT was ineffective. OVA-specific antibodies were detected following GG immunization with all three constructs, whereas only the OVA-SECR construct induced antibody production following intramuscular immunization. ...
- Altering conditions of DNA immunization allows control of immune response.
- Newspaper article from: Genomics & Genetics Weekly April 2, 2004 700+ words
...immunization route in DNA immunization allows manipulation...United States, "DNA immunization by intramuscular...Three ovalbumin (OVA) cDNA constructs...whereas only the OVA-SECR construct...and the route of DNA immunization." Morel and her...
- Infection spread inhibited by DNA immunization with C. trachomatis pgp3...
- Newspaper article from: Vaccine Weekly April 16, 2003 700+ words
...experiments with C3H/HeN mice, DNA immunization with the pgp3 gene of "Chlamydia...reported, "Overall, the pgp3-DNA immunization prevented salpinx infection in 94...Donati's group said. "Pgp3 DNA immunization induced both humoral and mucosal anti...
- Infection spread inhibited by DNA immunization with C. trachomatis pgp3...
- Magazine article from: Women's Health Weekly April 17, 2003 700+ words
...experiments with C3H/HeN mice, DNA immunization with the pgp3 gene of "Chlamydia...reported, "Overall, the pgp3-DNA immunization prevented salpinx infection in 94...Donati's group said. "Pgp3 DNA immunization induced both humoral and mucosal anti...
- Infection spread inhibited by DNA immunization with C. trachomatis pgp3 gene.
- Newspaper article from: Gene Therapy Weekly April 17, 2003 700+ words
...experiments with C3H/HeN mice, DNA immunization with the pgp3 gene of "Chlamydia...reported, "Overall, the pgp3-DNA immunization prevented salpinx infection in 94...Donati's group said. "Pgp3 DNA immunization induced both humoral and mucosal anti...
- DNA immunization offers new opportunities in vaccine research.
- Newspaper article from: Immunotherapy Weekly March 19, 2003 700+ words
...NewsRx.com & NewsRx.net) -- DNA immunization offers new opportunities in vaccine...Several advantages are associated with DNA immunization, e.g., cheap to produce, heat...Medical Microbiology and Immunology (DNA immunization - a new chance in vaccine research...
- DNA immunization offers new opportunities in vaccine research.(Brief Article)
- Newspaper article from: Vaccine Weekly March 19, 2003 700+ words
...NewsRx.com & NewsRx.net) -- DNA immunization offers new opportunities in vaccine...Several advantages are associated with DNA immunization, e.g., cheap to produce, heat...Medical Microbiology and Immunology (DNA immunization - a new chance in vaccine research...
- B virus glycoprotein antibodies induced by DNA immunization characterized.
- Newspaper article from: Gene Therapy Weekly January 23, 2003 700+ words
...antibodies to B virus glycoproteins can be generated by DNA immunization and used as diagnostic and research reagents." "Genes...Characterization of B virus glycoprotein antibodies induced by DNA immunization. Arch Virol, 2002;147(11):2057-2073). The...
- B virus glycoprotein antibodies induced by DNA immunization...
- Newspaper article from: Vaccine Weekly January 22, 2003 700+ words
...antibodies to B virus glycoproteins can be generated by DNA immunization and used as diagnostic and research reagents." "Genes...Characterization of B virus glycoprotein antibodies induced by DNA immunization. Arch Virol, 2002;147(11):2057-2073). The...
- IL-23 induces strong immune responses in hepatitis C DNA immunization.
- Newspaper article from: Drug Week March 5, 2004 700+ words
...does IL-12 after hepatitis C virus envelope protein 2 DNA immunization. "IL-23 is a heterodimeric cytokine consisting of p19...responses than IL-12 in hepatitis C virus envelope protein 2 DNA immunization. J Immunol, 2004;172(1):525-531). For additional...
- Immune responses to self-antigen after DNA immunization reported.
- Newspaper article from: Drug Week July 16, 2004 700+ words
...NewsRx.com & NewsRx.net) -- Scientists compare the immune response to a self-antigen after DNA immunization of HLA*A201/H-2Kb and HHD transgenic mice in a recent issue of Vaccine. "HHD mice which express human...
Source: HighBeam Research, Altering conditions of DNA immunization allows control of immune...