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X-linked gene elements leave women vulnerable to primary biliary cirrhosis.

Health & Medicine Week

| March 29, 2004 | COPYRIGHT 2009 NewsRX. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan. All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)Copyright

2004 MAR 29 - (NewsRx.com & NewsRx.net) -- X-linked gene elements leave women vulnerable to primary biliary cirrhosis.

"The mechanisms that cause the female predominance of primary biliary cirrhosis (PBC) are uncertain, but the X chromosome includes genes involved in immunological tolerance. We assessed the rate of X monosomy in peripheral white blood cells from 100 women with PBC, 50 with chronic hepatitis C, and 50 healthy controls, by fluorescence in-situ hybridization," wrote P. Invernizzi and colleagues, University of Milan, San Pablo School of Medicine.

"Frequency of X monosomy increased with age in all groups, but was significantly higher in women with…

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