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Postnatal steroid treatment and brain development.(Review)
Arch Dis Child Fetal Neonatal Ed 2004;89:F96-F100. doi: 10.1136/adc.2003.028696
This review examines the risk/benefit ratio of postnatal steroid treatment in preterm infants and correlates epidemiological data with experimental evidence on the effect of glucocorticosteroids on brain development.
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In 1972, Liggins and Howie (1) reported the first study showing the value of prenatal steroids given to mothers at risk of preterm delivery. Subsequently, many randomised trials confirmed that prenatal steroids reduce mortality and the incidence of respiratory distress syndrome and intraventricular haemorrhage in premature infants. (2-5) ...
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