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Retrospective study: predicting breast cancer response to chemotherapy.(Gynecology)
SAN ANTONIO -- Women with estrogen receptor-positive breast cancer are far less likely to respond to chemotherapy than are those with estrogen receptor-negative tumors, Dr. Aman Buzdar reported at a breast cancer symposium sponsored by the Cancer Therapy and Research Center.
This observation in a large retrospective study isn't in itself sufficient to change the widely followed practice of giving breast cancer patients tumor-shrinking neoadjuvant chemotherapy after surgery, followed by endocrine therapy in the subset of patients with estrogen receptor-positive disease.
It does, however, raise the possibility that patients with estrogen receptor-positive tumors may do well with endocrine therapy without chemotherapy, a hypothesis that warrants testing in a large clinical trial randomizing ...
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Estrogen receptor (ER)-positive breast cancer patients receive so much benefit from estrogen-blocking hormone therapy that undergoing chemotherapy may add little, if any...
Source: HighBeam Research, Retrospective study: predicting breast cancer response to...