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Possible screening tool; Chromosomally normal fetuses: nuchal translucency, heart defects linked.(News)

OB GYN News

| March 01, 2004 | Sullivan, Michele G. | COPYRIGHT 2004 International Medical News Group. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan.  All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)Copyright

NEW ORLEANS -- A chromosomally normal fetus with increased nuchal translucency is at significantly heightened risk of having a heart defect, Dr. Ray O. Bahado-Singh reported at the annual meeting of the Society for Maternal-Fetal Medicine.

Each millimeter increase in nuchal translucency doubles the risk of a fetal congenital heart defect, reported Dr. Bahado-Singh, a member of the First Trimester Maternal Serum Biochemistry and Fetal Nuchal Translucency Screening (BUN) Study Group. The finding suggests yet another use for nuchal translucency screening, he said.

"Up until now, universal screening for congenital heart defects has not been instituted because of the lack of good markers," said Dr. Bahado-Singh of the University of Cincinnati. "Family history and maternal disorders only account for about 5% of the babies born with these defects. Nuchal translucency already has a proven sensitivity and is cost-effective, so this screening could be an added component of aneuploidy studies."

Dr. Bahado-Singh presented data extracted from the BUN study, sponsored by the National Institute for Child Health and Development. The multicenter first-trimester screening study used maternal age, maternal levels of free [beta]-human chorionic gonadotropin and pregnancy-associated plasma protein A, and ultrasonographic ...

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