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HPV types, Ca link studied in young women: HPV 16, 18 implicated.(Gynecology)
PLAYA HERRADURA, COSTA RICA --Certain types of human papillomavirus are associated with a higher risk for cervical cancer and genital warts in young women, according to a study of 600 female university students.
Detection of viral types with high oncogenic potential could help identify women who are more likely to progress to cervical cancer. Many sexually active women are exposed to multiple types of human papillomavirus (HPV) during adolescence and their twenties.
"The peak age for carcinoma in situ is about 28 years old. So it's a lesion that develops early. Remember, you have to screen to detect," Laura Koutsky, Ph.D., said at a conference on vaginitis sponsored by Imedex.
Within 1 year of first intercourse, 30% of women tested positive for HPV infection in her study of sexually active women attending a university (Am. J. Epidemiol. 157[3]:218-26, 2003). Within 3 years, about 50% were infected.
Study participants were examined every 4 months. At 36 months, 47% of the 600 women had developed cytologic evidence of cervical squamous intraepithelial lesion. The average duration of the lesions was 5.5 months. Twenty-nine percent developed cytologic evidence of vaginal squamous intraepithelial lesion (average duration, 4.7 months), said Dr. Koutsky, who is professor of epidemiology at the University of Washington, Seattle.
At 36 months, 64% of the participants infected with HPV type 6 or 11 developed genital warts. "So if you have HPV 6 or 11, your risk for genital warts is high," she said.
There are more than 100 recognized HPV types. "Most of us think there is lots of HPV out there, but very few lesions. That is not the case," she said.
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Source: HighBeam Research, HPV types, Ca link studied in young women: HPV 16, 18...