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Home pregnancy kit and cervical washings may detect PPROM: small pilot study.(News)

OB GYN News

| February 15, 2004 | Sullivan, Michele G. | COPYRIGHT 2004 International Medical News Group. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan.  All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)Copyright

BOCA RATON, FLA. -- A small pilot study shows the potential of using a bedside pregnancy kit and cervical washings to detect premature preterm rupture of membranes.

When used to measure human chorionic gonadotropin in cervical washings of 52 women with PPROM, the method demonstrated a 95% positive predictive value, Dr. Amy Cooper said at the annual meeting of the South Atlantic Association of Obstetricians and Gynecologists.

In the study, Dr. Cooper's method was slightly more accurate than the 93% rate of nitrazine strip testing, in which false positives can result from specimen contamination with urine, blood, semen, or vaginal discharges caused by infection.

In discussing the paper, Dr. Kurt R. Stockstill of Roanoke, Va., said the pilot study could represent a quick, noninvasive, and cost-effective method of identifying PPROM in a carefully selected patient population. The pregnancy-kit method should be tested against the standard, amniocentesis with dye infusion, he said.

"However, amniocentesis with dye infusion carries an inherent risk of morbidity and is very expensive. The minimal cost of this is an attractive aspect of this study, and its technology is readily available."

Dr. Cooper, a resident at the Medical University of South Carolina, Charleston, received the John R. McCain Presentation award for her work. Her prospective, controlled study was based on previous research showing greatly increased levels of HCG in the cervical-vaginal washings of women with PPROM. In women with intact membranes, HCG levels average 37.8 mIU/mL in the first trimester, 9.5 mIU/mL in the second trimester, and 6.3 mIU/mL in the third trimester. Washings in women with PPROM contained an average of 400 mIU/mL of HCG.

Dr. Cooper tested her method using ...

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