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Modern treatments for severe depression still have poor long term outcome.(Prognosis)
Q Has the long term prognosis of people with severe depression changed as a result of the increased use of modern treatments such as antidepressants and psychological therapy?
METHODS
* Design: Long term follow up of observational study.
* Setting: Local treatment centres in Cambridgeshire, UK; recruitment 1990 to 1992.
* Population: 70 people diagnosed as having moderate to severe primary unipolar major depression according to the Research Diagnostic Criteria (RDC). Exclusions: concurrent major physical or psychiatric illnesses. Participants had been recruited as part of a 30 month short term follow up study. 69 (99%) of the original sample were followed up.
* Prognostic foctors: Participants were contacted 8 to 11 years after recruitment. A psychiatrist blinded to the original study results reviewed their psychiatric and general practice case notes. The psychiatrist interviewed the participants using an adapted Longitudinal Interview Follow-up Evaluation (LIFE) to assess the number and length of depressive episodes during follow up.
* Outcomes: Recurrence of depression (as diagnosed by RDC).
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