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LPA type-2 regulates a host of growth factors to control ovarian activity.
2004 MAR 4 - (NewsRx.com & NewsRx.net) -- LPA type-2 regulates a host of growth factors to control ovarian activity.
According to published research from the United States, "the lipid growth factor lysophosphatidic acid (LPA) is produced by ovarian cancer cells in quantities sufficient to attain concentrations of up to 10 microM. An autocrine circuit was demonstrated when ovarian cancer cells, but not normal ovarian surface epithelial cells, were proven to express LPA[subscript]2 (Edg-4) and LPA[subscript]3 (Edg-7) G protein-coupled receptors for LPA. Human LPA[subscript]2 now has been expressed transgenically in C57BL/6 mouse ovaries under direction of the alpha-inhibin large promoter."
"Human LPA[subscript]2 mRNA and protein were detected in all transgenic (TG) mouse ovaries at levels far higher than in other tissues and at least five-fold higher than in cultured lines of human ovarian cancer cells, with the expected sex cord-stromal distribution," reported M.C. Huang and colleagues, University of California, San Francisco, Medical Center.
"Most LPA[subscript]2 TG ovaries produced significantly higher levels than non-TG ovaries of type A, but not type B, vascular endothelial growth factor (VEGF), isomers of VEGF-A, and ...
- LPA type-2 regulates a host of growth factors to control ovarian activity.
- Newspaper article from: Cancer Weekly March 2, 2004 700+ words
...promoter." "Human LPA[subscript]2 mRNA...University of California, San Francisco, Medical Center. "Most LPA[subscript]2 TG...coupled receptor (LPA[subscript]2...University California San Francisco, Med Center, Department...
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...Solutions Division (SSD) of LPA Software, Inc. (LPA) for $10 million in cash. SSD...industry trade show held in July in San Francisco, ADE introduced a series of software...Peckham, founder and President of LPA Software, Inc. stated about...
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...When employees at the architecture firm LPA Inc., in Roseville, Calif., want...stations," Ms. Bjerrisgaard says. At LPA, green initiatives go far beyond worms...marketing at Golden Gate University in San Francisco. The most dedicated employees go out...
- (Weather) New LPA spotted near Pangasinan.
- News wire article from: Philippines News Agency September 8, 2009 700+ words
...bureau said. At 2:00 p.m. today, a Low Pressure Area (LPA) was seen 230 kilometers west of Dagupan City, the Philippine...passengers were brought to Santiago Beach Resort, Brgy. Santiago, San Francisco, Camotes Island for medical check-up and all were found...
- LPA Brings Multi-tiered E-Trading Communities(TM) On-line With New LPATrade;...
- Press release article from: PR Newswire April 17, 2000 700+ words
...N.Y., April 17 /PRNewswire/ -- LPA, Inc., the leading provider of planning...four enables Web-wide global exchanges. LPA takes an active role in soliciting and helping...controls required by each participant. LPA customers trading at tier two have automated...
- LPA exerts antiadrenergic effects on contraction in human, rodent myocardium.
- Newspaper article from: Heart Disease Weekly May 4, 2003 700+ words
...NewsRx.net) -- Lysophosphatidic acid (LPA) exerts antiadrenergic effects on contraction...rodent myocardium. "Lysophosphatidic acid (LPA) is a phospholipid messenger, which is...leukocytes. "This study examined the effects of LPA on myocardial contractility and characterized...
- LPA Teams with Asera to Build Multi-tiered E-Trading Communities.
- Press release article from: PR Newswire April 7, 2000 700+ words
...Markets NEW YORK, Feb. 29 /PRNewswire/ -- LPA, Inc., the leading provider of planning...business-to-business demand chain. LPA will be leveraging Asera's eService...said Mike Fabiaschi, president and CEO of LPA. "We built our first e-trading community...
- Antagonists of LPA receptors might help to prevent thrombus formation.
- Newspaper article from: World Disease Weekly October 12, 2004 700+ words
...Biochemistry, "Lysophosphatidic acid (LPA) has been identified as a biologically...activated platelets. The evidence that LPA has thrombogenic and atherogenic activities...Supporting the thrombogenic activity of LPA, analysis of the core region of human carotid...
