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Storing too much iron may put healthy women at higher risk for diabetes.
2004 MAR 4 - (NewsRx.com & NewsRx.net) -- Higher amounts of iron stores in the blood are associated with an increased risk of type 2 diabetes in healthy women who have no known diabetes risk factors, according to a study in the February 11, 2004, issue of the Journal of the American Medical Association (JAMA).
Excessive iron stores can cause type 2 diabetes among patients with hemochromatosis, a genetic defect in the regulation of iron absorption. It isn't clear, however, if moderately elevated iron stores predict the risk of developing type 2 diabetes among healthy individuals.
In their JAMA paper, Rui Jiang, MD, DrPH, from the Harvard School of Public Health, Boston, and colleagues noted that iron excess seems to contribute initially to insulin resistance and subsequently to decreased insulin secretion.
Jiang's team evaluated biomarkers reflecting iron stores, including plasma ferritin (an iron-protein complex in blood) concentration and the ratio of the concentrations of transferrin receptors (iron transporters) to ferritin in relation to the development of type 2 diabetes in apparently healthy middle-aged women enrolled in the Nurses' Health Study. Of the 32,826 women who provided blood samples during 1989-1990 and were free of diagnosed diabetes, cardiovascular disease, and cancer, 698 developed diabetes during 10 years of follow-up. The researchers randomly selected 716 women from the study to be in the control group who were free from diabetes.
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